Recombinant Human CLCA2, GST-tagged

• Cat.No.: CLCA2-11274H
• Product Overview: Recombinant Human CLCA2 protein, fused to GST-tag, was expressed in E.coli and purified by GSH-sepharose.

Specification

• Species: Human
• Source: E.coli
• Tag: GST
• Protein Length: 595-901a.a.
• Description: The protein encoded by this gene belongs to the calcium sensitive chloride conductance protein family. To date, all members of this gene family map to the same site on chromosome 1p31-p22 and share high degrees of homology in size, sequence and predicted structure, but differ significantly in their tissue distributions. Since this protein is expressed predominantly in trachea and lung, it is suggested to play a role in the complex pathogenesis of cystic fibrosis. It may also serve as adhesion molecule for lung metastatic cancer cells, mediating vascular arrest and colonization, and furthermore, it has been implicated to act as a tumor suppressor gene for breast cancer.
• Storage: The protein is stored in PBS buffer at -20℃. Avoid repeated freezing and thawing cycles.
• Storage Buffer: 1M PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8. ) added with 100mM GSH and 1% Triton X-100,15%glycerol.

Gene Information

• Gene Name: CLCA2 chloride channel accessory 2 [ Homo sapiens ]
• Official Symbol: CLCA2
• Synonyms: CLCA2; chloride channel accessory 2; chloride channel regulator 2 , chloride channel, calcium activated, family member 2; calcium-activated chloride channel regulator 2; CLCRG2; hCLCA2; hCaCC-3; chloride channel regulator 2; calcium-activated chloride channel-2; calcium-activated chloride channel protein 3; CLCA family member 2, chloride channel regulator; calcium-activated chloride channel family member 2; chloride channel, calcium activated, family member 2; CACC; CACC3; CaCC-3; FLJ97885
• Gene ID: 9635
• mRNA Refseq: NM_006536
• Protein Refseq: NP_006527
• MIM: 604003
• UniProt ID: Q9UQC9
• Chromosome Location: 1p22.3
• Pathway: Alpha6-Beta4 Integrin Signaling Pathway, organism-specific biosystem; Olfactory transduction, organism-specific biosystem; Olfactory transduction, conserved biosystem; Pancreatic secretion, organism-specific biosystem; Pancreatic secretion, conserved biosystem
• Function: chloride channel activity; ligand-gated ion channel activity