Recombinant Human CHUK, His-tagged

• Cat.No.: CHUK-675H
• Product Overview: Recombinant human full length CHUK, His-tagged was expressed ininsect cells.MW = 88.7 kDa.

Specification

• Cat. No.: CHUK-675H
• Description: Inhibitor of nuclear factor kappa-B kinase subunit alpha (IKK-α) also known as conserved helix-loop-helix ubiquitous kinase (CHUK) is a protein kinase that in humans is encoded by the CHUK gene. IKK-α is part of the IκB kinase complex that plays an important role in mediating the inflammatory response. In addition, IKK-α functions independently of the IκB kinase complex to regulate epidermal differentiation.
• Source: Insect cells.
• Formulation: Liquid in 50 mM Tris, pH 7.5 + 150 mM NaCl + 0.5 mM EDTA + 0.02% Triton X-100 + 2mM DTT + 50% glycerol.
• Specific Activity: 38 nmole of phosphate transferred to myelin basic protein (MBP) per minute per mg of total protein at 30°C. Activity determined at a final protein concentration of 8.33 µg/ml.
• Storage & Stability: Stable for 6 months in working aliquots at -80°C. Avoid repeated freeze-thaw cycles.
• Full Length: Full L.

Gene Information

• Gene Name: CHUK conserved helix-loop-helix ubiquitous kinase [ Homo sapiens ]
• Synonyms:
  conserved helix-loop-helix ubiquitous kinase; IKK1; IKKA; IKBKA; TCF16; NFKBIKA; IKK-alpha; CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha; TCF-16; IKK-a kinase; ikappaB kinase; I-kappa-B kinase 1; I-kappa-B kinase alpha; I-kappa-B kinase-alpha; transcription factor 16; IkB kinase alpha subunit; conserved helix-loop ubiquitous kinase; Nuclear factor NFkappaB inhibitor kinase alpha; nuclear factor NF-kappa-B inhibitor kinase alpha;Nuclear factor NF-kappa-B inhibitor kinase alpha; Transcription factor 16; IkappaB kinase; IKK-A; EC 2.7.11.10
• Gene ID: 1147
• mRNA Refseq: NM_001278
• Protein Refseq: NP_001269
• MIM: 600664
• UniProt ID: O15111
• Chromosome Location: 10q24-q25
• Pathway: Acute myeloid leukemia; Adipocytokine signaling pathway; Apoptosis; B cell receptor signaling pathway; Chagas disease; Chemokine signaling pathway; Chronic myeloid leukemia; Cytosolic DNA-sensing pathway; Epithelial cell signaling in Helicobacter pylori infection; MAPK signaling pathway; NOD-like receptor signaling pathway; Pancreatic cancer; Pathways in cancer; Prostate cancer; RIG-I-like receptor signaling pathway; Shigellosis; Small cell lung cancer; T cell receptor signaling pathway; Toll-like receptor signaling pathway; Signaling in Immune system
• Function: ATP binding; IkappaB kinase activity; identical protein binding; nucleotide binding; protein binding; protein heterodimerization activity; transferase activity