Recombinant Human chromobox 8 Protein, His tagged

• Cat.No.: CBX8-200H
• Product Overview: Recombinant human CBX8 protein (Q9HC52) (Ala 83-Lys 360) with a His tag at the C-terminus was expressed in E. coli.

Specification

• Species: Human
• Source: E.coli
• Tag: His
• Protein Length: 83-360aa
• Description: Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. The human orthologuous proteins of Drosophila Polycomb group protein Pc, CBX2, CBX4, CBX6, CBX7 and CBX8, show distinct nuclear localizations, contribute differently to transcriptional repression, and appear to be part of distinct PRC1-like protein complexes.
• Tag: C-His
• Molecular Mass: 32 kDa
• Endotoxin: Less than 1.0 EU/μg by the LAL method.
• Purity: >95% as determined by SDS-PAGE.
• Storage: Please avoid repeated freeze-thaw cycles. Samples are stable for up to twelve months from date of receipt at -20 to -80 centigrade. It is recommended that aliquot the reconstituted solution to minimize freeze-thaw cycles.
• Storage Buffer: Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4, 5% Trehalose, 5% mannitol.
• Reconstitution: Reconstitute at 250 μg/mL in sterile water.

Gene Information

• Gene Name: CBX8 chromobox 8 [ Homo sapiens (human) ]
• Official Symbol: CBX8
• Synonyms: CBX8; chromobox homolog 8; chromobox homolog 8 (Drosophila Pc class); chromobox protein homolog 8; HPC3; Pc class 3 homolog (Drosophila); PC3; polycomb 3; RC1; rectachrome 1; Pc class 3 homolog; chromobox homolog 8 (Pc class homolog, Drosophila)
• Gene ID: 57332
• mRNA Refseq: NM_020649
• Protein Refseq: NP_065700
• MIM: 617354
• UniProt ID: Q9HC52