CBX8
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Official Full Name
chromobox homolog 8 -
Overview
The family of Heterochromatin Proteins ("Chromobox Homolog", CBX) are highly conserved adapter molecules,Which have important functions in the cell nucleus. These functions include gene repression by heterochromatin formation, transcriptional activation, regulation of binding of cohesion complexes to centromere, sequesteration of genes to nuclear periphery, transcriptional arrest, maintenance of heterochromatin integrity, gene repression at single nucleosome level and gene repression by heterochromatization of euchromatin. -
Synonyms
CBX8;chromobox homolog 8;chromobox homolog 8 (Drosophila Pc class);chromobox protein homolog 8;HPC3;Pc class 3 homolog (Drosophila);PC3;polycomb 3;RC1;rectachrome 1;Pc class 3 homolog;chromobox homolog 8 (Pc class homolog, Drosophila)
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| CBX8-0486H | Recombinant Human CBX8 Protein, GST-Tagged | Wheat Germ | Human | GST |
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| CBX8-7800HCL | Recombinant Human CBX8 293 Cell Lysate | HEK293 | Human | Non |
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| CBX8-200H | Recombinant Human chromobox 8 Protein, His tagged | E. coli | Human | His | 83-360aa |
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| CBX8-2784HF | Recombinant Full Length Human CBX8 Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 389 amino acids |
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| CBX8-371H | Recombinant Human CBX8 protein, His&Myc-tagged | E.coli | Human | His&Myc | 1-389aa |
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| CBX8-6463H | Recombinant Human CBX8 protein(1-389aa), His-tagged | E. coli | Human | His | 1-389aa |
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Involved Pathway
CBX8 involved in several pathways and played different roles in them. We selected most pathways CBX8 participated on our site, such as Cellular Senescence,Cellular responses to stress,Metabolism of proteins, which may be useful for your reference. Also, other proteins which involved in the same pathway with CBX8 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Post-translational protein modification | DPH5,ADAMTS13,DHPS,ADAMTS15,MUCL1,CNIH2,DPH1,TMED10,NANP,CBX4 |
| Metabolism of proteins | C8orf84,EEF1D,TRAPPC2L,FXC1,PAM16,DPAGT1,ODAM,PDIA6,TIMM17A,GNE |
| SUMOylation of DNA damage response and repair proteins | NSMCE1,RNF2,SMC5,SMC6,PHC2,SCMH1,PHC1,EID3,NSMCE2,NSMCE4A |
| Cellular responses to stress | SUZ12A,AGO1,C11orf73,WIPI2,CBX6A,MAP1LC3C,HMGA1B,RBB4L,HBXIP,EGLN3 |
| Oxidative Stress Induced Senescence | CBX4,CBX8B,BMI1B,CBX6,SUZ12A,PHC2,PHC3,SCMH1,CBX8A,EED |
| SUMO E3 ligases SUMOylate target proteins | SMC5,RING1,NSMCE2,SMC6,PHC2,NSMCE1,PHC3,NSMCE4A,CBX4,EID3 |
| SUMOylation | NSMCE1,RING1,SMC6,NSMCE2,UBA2,PHC2,SAE1,PHC3,RNF2,SCMH1 |
| Cellular Senescence | POT1,RBB4L,UBN1,HIST1H1A,TINF2,RBBP4,BMI1A,HIST2H3C,CDKN2B,EED |
Protein Function
CBX8 has several biochemical functions, for example, methylated histone binding,protein binding,single-stranded RNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CBX8 itself. We selected most functions CBX8 had, and list some proteins which have the same functions with CBX8. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| methylated histone binding | LRWD1,PHF2,RRP8,CDYL2,PHF13,CBX7,CBX5,ING3,TP53BP1,ING2 |
| ubiquitin-protein transferase activator activity | AUP1,UBE2L3,RING1,FBXW7 |
| single-stranded RNA binding | JMJD6,ANXA1,SNRPC,TLR7,DDX58,LUZP4,PIWIL1,DHX58,HMGB1,CBX6 |
| protein binding | PIDD1,FOXO3,EPC1,SPHK2,RAB39A,RDH12,TMED2,FCNA,ZNF821,LATS2 |
Interacting Protein
CBX8 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CBX8 here. Most of them are supplied by our site. Hope this information will be useful for your research of CBX8.
BMI1;RNF2
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