Recombinant Human Chromatin Modifying Protein 2B, His-tagged

• Cat.No.: CHMP2B-4985H
• Product Overview: Recombinant human CHMP2B protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques.

Specification

• Cat. No.: CHMP2B-4985H
• Description: CHMP2B belongs to the vacuolar sorting protein family. It is a component of the ESCRT-III complex. This complex is crucial for sorting endosomal articles into multivesicular bodies (MVBs), and are also required for the formation of these bodies. CHMP2B widely expressed in brain, heart, skeletal muscle, small intestine, pancreas, lung, placenta and leukocytes.
• Concentration: 0.5 mg/ml
• Source: Human
• Host: E.coli
• Form: Supplied as a liquid in 20mM Tris-HCl buffer, pH 8.0, containing 10% glycerol, 1mM DTT and 0.1M NaCl.
• Purity: > 90 % by SDS - PAGE
• Sequence: 1-213 amino acids: MGSSHHHHHH SSGLVPRGSH MASLFKKKTV DDVIKEQNRE LRGTQRAIIR DRAALEKQEK QLELEIKKMA KIGNKEACKV LAKQLVHLRK QKTRTFAVSS KVTSMSTQTK VMNSQMKMAG AMSTTAKTMQ AVNKKMDPQK TLQTMQNFQK ENMKMEMTEE MINDTLDDIF DGSDDEEESQ DIVNQVLDEI GIEISGKMAK APSAARSLPS ASTSK
• Molecular Mass: 26.1 kDa
• Applications: SDS-PAGE
• Storage: Store at 4 deg C for short term storage (1/2 weeks). Aliquot and store at -20 deg C or - 70 deg C for long term storage. Avoid repeated freeze/thaw cycles.

Gene Information

• Gene Name: CHMP2B chromatin modifying protein 2B [ Homo sapiens ]
• Official Symbol: CHMP2B
• Synonyms: CHMP2B; DMT1; VPS2B; VPS2-2; CHMP2.5; DKFZp564O123; charged multivesicular body protein 2b; hVps2-2; VPS2 homolog B; OTTHUMP00000213795; OTTHUMP00000213812; OTTHUMP00000213813; chromatin-modifying protein 2b; vacuolar protein sorting-associated protein 2-2
• Gene ID: 25978
• mRNA Refseq: NM_014043
• Protein Refseq: NP_054762
• MIM: 609512
• UniProt ID: Q9UQN3
• Chromosome Location: 3p11.2
• Pathway: ESCRT-III complex; Endocytosis; Endosomal Sorting Complex Required For Transport (ESCRT); Membrane Trafficking
• Function: protein domain specific binding