Recombinant Human Chemokine (C-C motif) ligand 11,His-tagged

• Cat.No.: CCL11-27H
• Product Overview: Recombinant Human Eotaxin His Tag produced in E.Coli is a single, non-glycosylated polypeptide chain containing 74 amino acids fragment (24-87) corresponding to the mature Eotaxin protein and having a molecular mass of 8345.9 Dalton with an amino-terminal hexahistidine tag. The Eotaxin-His is purified by proprietary chromatographic techniques.

Specification

• Species: Human
• Source: E.coli
• Tag: His
• Protein Length: 24-87 a.a.
• Description: Chemokine (C-C motif) ligand 11 (CCL11) is a small cytokine belonging to the CC chemokine family that is also known as eotaxin. CCL11 selectively recruits eosinophils by inducing their chemotaxis, and therefore, is implicated in allergic responses. The effects of CCL11 are mediated by its binding to a G-protein-linked receptor known as a chemokine receptor. Chemokine receptors for which CCL11 is a ligand include CCR2, CCR3 and CCR5. The gene for human CCL11 (scya11) is encoded on three exons and is located on chromosome 17.
• Physical Appearance: Sterile Filtered clear solution.
• Purity: Greater than 95.0% as determined by: (a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE
• Formulation: Eotaxin-His is supplied in 1x PBS and 50% glycerol.
• Storage: Lyophilized Eotaxin although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution CCL11 should be stored at 4°Cbetween 2-7 days and for future use below -18°C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles.

Gene Information

• Gene Name: CCL11 chemokine (C-C motif) ligand 11 [ Homo sapiens ]
• Synonyms: CCL11; chemokine (C-C motif) ligand 11; C-C motif chemokine 11; eotaxin; eotaxin-1; Eosinophil chemotactic protein; MGC22554; Small-inducible cytokine A11; small inducible cytokine A11; SCYA11; small inducible cytokine subfamily A (Cys-Cys), member 11 (eotaxin)
• Gene ID: 6356
• mRNA Refseq: NM_002986
• Protein Refseq: NP_002977
• MIM: 601156
• UniProt ID: P51671
• Chromosome Location: 17q21.1-q21.2
• Pathway: Asthma; Chemokine signaling pathway; Cytokine-cytokine receptor interaction
• Function: chemokine activity