Recombinant Human Cell Division Cycle 37 Homolog (S. cerevisiae)

• Cat.No.: CDC37-331H
• Product Overview: Recombinant CDC37 protein was expressed in E.coli and purified by using conventional chromatography techniques (378 aa, 44.4 kDa).

Specification

• Species: Human
• Source: E.coli
• Tag: Non
• Description: CDC37, an essential gene in Saccharomyces cerevisiae, interacts genetically with multiple protein kinases. Cdc37 associates with the heat-shock protein 90 (Hsp90) molecular chaperone as one of several auxiliary proteins that are collectively referred to as Hsp90 co-chaperones. Cdc37 up-regulation is a common early event in some localized human cancers.
• Formulation: Liquid. In 20 mM Tris-HCl buffer (pH 8.0) containing 10% glycerol.
• Molecular Weight: 44.4 kDa (378aa).
• Purity: > 95% by SDS – PAGE.
• Concentration: 1 mg/ml (determined by Bradford assay).
• Endotoxin Level: < 1.0 EU per 1 μg of protein (determined by LAL method).
• Sequence: MVDYSVWDHI EVSDDEDETH PNIDTASLFR WRHQARVERM EQFQKEKEEL DRGCRECKRK VAECQRKLKE LEVAEGGKAE LERLQAEAQQ LRKEERSWEQ KLEEMRKKEK SMPWNVDTLS KDGFSKSMVN TKPEKTEEDS EEVREQKHKT FVEKYEKQIK HFGMLRRWDD SQKYLSDNVH LVCEETANYL VIWCIDLEVE EKCALMEQVA HQTIVMQFIL ELAKSLKVDP RACFRQFFTK IKTADRQYME GFNDELEAFK ERVRGRAKLR IEKAMKEYEE EERKKRLGPG GLDPVEVYES LPEELQKCFD VKDVQMLQDA ISKMDPTDAK YHMQRCIDSG LWVPNSKASE AKEGEEAGPG DPLLEAVPKT GDEKDVSV
• Storage: Can be stored at +4°C short term (1-2 weeks). For long term storage, aliquot and store at -20°C or -70°C. Avoid repeated freezing and thawing cycles.

Gene Information

• Gene Name: CDC37
• Synonyms: CDC37; cell division cycle 37 homolog (S. cerevisiae); CDC37 cell division cycle 37 homolog (S. cerevisiae); CDC37A; P50CDC37; p50Cdc37; cell division cycle 37 protein; CDC37 cell division cycle 37 homolog; CDC37 (cell division cycle 37, S. cerevisiae, homolog); Hsp90 co-chaperone Cdc37; Hsp90 chaperone protein kinase-targeting subunit; cell division cycle 37 homolog (S. cerevisiae).
• Gene ID: 11140
• mRNA Refseq: NM_007065.3
• Protein Refseq: NP_008996.1
• MIM: 605065
• UniProt ID: Q16543
• Chromosome Location: 19p13.2
• Function: Hsp90 protein binding; unfolded protein binding.