CDC37
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Official Full Name
cell division cycle 37 homolog -
Overview
CDC37 is an important component of the HSP90 chaperone complex. It was initially identified for its involvement in cell-cycle progression and was later found to have a much broader role as a chaperone for a wide variety of kinases and other proteins. CDC3 -
Synonyms
CDC37;cell division cycle 37 homolog (S. cerevisiae);CDC37 (cell division cycle 37, S. cerevisiae, homolog) , CDC37 cell division cycle 37 homolog (S. cerevisiae);hsp90 co-chaperone Cdc37;CDC37 (cell division cycle 37;S. cerevisiae;homolog)
Recombinant Proteins
- Human
- Zebrafish
- Rat
- Mouse
- Chicken
- E.coli
- Insect Cells
- Wheat Germ
- Mammalian Cells
- In Vitro Cell Free System
- HEK293
- GST
- His
- T7
- Non
- Fc
- Flag
- DDK
- Myc
- Avi
Involved Pathway
CDC37 involved in several pathways and played different roles in them. We selected most pathways CDC37 participated on our site, such as AhR pathway,Constitutive Signaling by EGFRvIII,Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants, which may be useful for your reference. Also, other proteins which involved in the same pathway with CDC37 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Diseases of signal transduction | RLBP1,TNKS,FKBP1A,JAG2,OPN1MW2,CPSF6,OPN1SW,JAG1,OPN1LW,FGFR1OP |
| AhR pathway | AIP,AHRR,AHR,EGFR,JUN,CYP1A1,CYP1B1,NQO1,CYP1A2,JUND |
| Disease | KPNA5,OPN1MW,STRA6,AP2M1,CHMP4C,GPC5,KPNA3,FDX1L,SYT2,SUPT4H1 |
| PI3K-Akt signaling pathway | EFNA2,CSF1R,SGK2,CSH1,LOC608458,CSF1,PIK3AP1,CSH2,EFNA4,CSF3 |
| LKB1 signaling events | MAP2,SIK3,CTSD,MARK4,STK11IP,MARK2 |
| Signal Transduction | FSTB,CCL19A.2,SST,NMT1B,DEPDC1B,EMR2,KAL1,PROKR2,OXGR1A.3,PTH |
Protein Function
CDC37 has several biochemical functions, for example, Hsp90 protein binding,chaperone binding,heat shock protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CDC37 itself. We selected most functions CDC37 had, and list some proteins which have the same functions with CDC37. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| unfolded protein binding | CRYAA,HSP90AA1,SIL1,CCT3,H2-KE2,TTC1,NAP1L4,CCT2,CDC37L1,DNAJB4 |
| chaperone binding | SYVN1,PRNP,UBL4A,TIMM9,TBCA,CLU,HSPE1,ATP1A3,BAG4,ATP1A1 |
| kinase binding | RB1,RASGRP3,HPCA,MIDN,DUSP12,CDC6,TAX1BP1,EMP2,PFKFB1,BARD1 |
| protein C-terminus binding | ITGB3BP,SCLT1,RABAC1,PIAS3,TAX1BP3,SIAH1,SNTG1,PPP2CA,SIRT1,PDZD11 |
| protein binding | FHL5,DPYSL3,LSM11,APOL1,MIIP,STYX,RAB39A,SLC40A1,DOK3,RIPPLY1 |
| mitogen-activated protein kinase kinase kinase binding | MAPK9,MAPK8IP3,MAP4K2,MAP2K1,STK38,TRAF2,TCF3,PPEF2,CDC42,MAP3K11 |
| Hsp90 protein binding | FKBP6,USP19,NASP,ERN1,PPID,AHR,TELO2,NPAS2,CSNK2A1,HIF1A |
| heat shock protein binding | EEF1D,DNAJC9,DNAJA2,KCNJ11,HSPA6,DMPK,PACRG,PARK2,PDXP,NFKBIA |
| protein kinase B binding | BCL10,RARA,TRAF6,CCDC88A,APPL1,ANKRD2,PINK1,PDE3B,BAD |
Interacting Protein
CDC37 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CDC37 here. Most of them are supplied by our site. Hope this information will be useful for your research of CDC37.
HSP90AA1;LRRK2
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References
- Cao, FF; Xu, LM; et al. IP-FCM Platform Detects the Existence and Regulator-Caused Dissociation of Components in Naturally Assembled HSP90 Complex. CYTOMETRY PART A 85:359-367(2014).
- Du, C; Wingard, JR; et al. Serum IgG Responses against Aspergillus Proteins before Hematopoietic Stem Cell Transplantation or Chemotherapy Identify Patients Who Develop Invasive Aspergillosis. BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION 18:1927-1934(2012).
