Recombinant Human CDC37

• Cat.No.: CDC37-26223TH
• Product Overview: Recombinant CDC37 protein was expressed in E.coli and purified by using conventional chromatography techniques.

Specification

• Species: Human
• Source: E.coli
• Tag: Non
• Protein Length: 1-378aa
• Description: The protein encoded by this gene is highly similar to Cdc 37, a cell division cycle control protein of Sacchromyces cerevisiae. This protein is a molecular chaperone with specific function in cell signal transduction. It has been shown to form complex with Hsp90 and a variety of protein kinases including CDK4, CDK6, SRC, RAF-1, MOK, as well as eIF2 alpha kinases. It is thought to play a critical role in directing Hsp90 to its target kinases.
• Form: Liquid in 20mM Tris pH 8.0, 10% glycerol Molecular Weight: 44.4kDa (378aa)
• Molecular Mass: 44.4Da (378aa), confirmed by MALDI-TOF.
• AA Sequence: MVDYSVWDHI EVSDDEDETH PNIDTASLFR WRHQARVERM EQFQKEKEEL DRGCRECKRK VAECQRKLKE LEVAEGGKAE LERLQAEAQQ LRKEERSWEQ KLEEMRKKEK SMPWNVDTLS KDGFSKSMVN TKPEKTEEDS EEVREQKHKT FVEKYEKQIK HFGMLRRWDD SQKYLSDNVH LVCEETANYL VIWCIDLEVE EKCALMEQVA HQTIVMQFIL ELAKSLKVDP RACFRQFFTK IKTADRQYME GFNDELEAFK ERVRGRAKLR IEKAMKEYEE EERKKRLGPG GLDPVEVYES LPEELQKCFD VKDVQMLQDA ISKMDPTDAK YHMQRCIDSG LWVPNSKASE AKEGEEAGPG DPLLEAVPKT GDEKDVSV
• Endotoxin: < 1.0 eu per 1 microgram of protein (determined by lal
• Purity: >95% by SDS - PAGE
• Applications: SDS-PAGE
• Storage: Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -70C. Avoid repeated freezing and thawing cycles.
• Concentration: 1 mg/ml (determined by Bradford assay)

Gene Information

• Gene Name: CDC37 cell division cycle 37 [ Homo sapiens (human) ]
• Official Symbol: CDC37
• Synonyms: CDC37; P50CDC37; cell division cycle 37 homolog (S. cerevisiae); CDC37 (cell division cycle 37, S. cerevisiae, homolog); CDC37 cell division cycle 37 homolog (S. cerevisiae); CDC37 cell division cycle 37 homolog; Hsp90 co-chaperone Cdc37; Hsp90 chaperone protein kinase-targeting subunit; p50Cdc37; CDC37A
• Gene ID: 11140
• mRNA Refseq: NM_007065
• Protein Refseq: NP_008996
• MIM: 605065
• UniProt ID: Q16543
• Chromosome Location: 19p13.2
• Pathway: PI3K-Akt signaling pathway; Signal Transduction; Signaling by constitutively active EGFR
• Function: Hsp90 protein binding; Heat shock protein binding; protein binding; unfolded protein binding