Recombinant Human CEBPA protein, His-tagged

• Cat.No.: CEBPA-153H
• Product Overview: Recombinant Human CEBPA fused with His tag at N-terminal was expressed in E. coli.

Specification

• Species: Human
• Source: E.coli
• Tag: His
• Description: This intronless gene encodes a transcription factor that contains a basic leucine zipper (bZIP) domain and recognizes the CCAAT motif in the promoters of target genes. The encoded protein functions in homodimers and also heterodimers with CCAAT/enhancer-binding proteins beta and gamma. Activity of this protein can modulate the expression of genes involved in cell cycle regulation as well as in body weight homeostasis. Mutation of this gene is associated with acute myeloid leukemia. The use of alternative in-frame non-AUG (GUG) and AUG start codons results in protein isoforms with different lengths. Differential translation initiation is mediated by an out-of-frame, upstream open reading frame which is located between the GUG and the first AUG start codons.
• Form: 25mM Tris, pH8.0, 150 mM NaCl, 10% glycerol, 1 % Sarkosyl.
• Molecular Mass: 37.4 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Concentration: >50 ug/mL as determined by microplate BCA method
• Publications:
  Adiponectin GWAS loci harboring extensive allelic heterogeneity exhibit distinct molecular consequences (2020)

Gene Information

• Gene Name: CEBPA CCAAT/enhancer binding protein (C/EBP), alpha [ Homo sapiens ]
• Official Symbol: CEBPA
• Synonyms: CEBPA; CCAAT/enhancer binding protein (C/EBP), alpha; CEBP; CCAAT/enhancer-binding protein alpha; C/EBP alpha; C/EBP-alpha
• Gene ID: 1050
• mRNA Refseq: NM_004364
• Protein Refseq: NP_004355
• MIM: 116897
• UniProt ID: P49715