Recombinant Human CDKL5, GST-tagged

• Cat.No.: CDKL5-11060H
• Product Overview: Recombinant Human CDKL5 protein, fused to GST-tag, was expressed in E.coli and purified by GSH-sepharose.

Specification

• Species: Human
• Source: E.coli
• Tag: GST
• Protein Length: N-term-301a.a.
• Description: The protein encoded by this gene shares strong similarity with Saccharomyces cerevisiae Cdc23, a protein essential for cell cycle progression through the G2/M transition. This protein is a component of anaphase-promoting complex (APC), which is composed of eight protein subunits and highly conserved in eukaryotic cells. APC catalyzes the formation of cyclin B-ubiquitin conjugate that is responsible for the ubiquitin-mediated proteolysis of B-type cyclins. This protein and 3 other members of the APC complex contain the TPR (tetratricopeptide repeat), a protein domain important for protein-protein interaction.
• Storage: The protein is stored in PBS buffer at -20℃. Avoid repeated freezing and thawing cycles.
• Storage Buffer: 1M PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8. ) added with 100mM GSH and 1% Triton X-100,15%glycerol.

Gene Information

• Gene Name: CDKL5 cyclin-dependent kinase-like 5 [ Homo sapiens ]
• Official Symbol: CDKL5
• Synonyms: CDKL5; cyclin-dependent kinase-like 5; serine/threonine kinase 9 , STK9; EIEE2; serine/threonine kinase 9; serine/threonine-protein kinase 9; cyclin dependent kinase 5 transcript; ISSX; STK9
• Gene ID: 6792
• mRNA Refseq: NM_003159
• Protein Refseq: NP_003150
• MIM: 300203
• UniProt ID: O76039
• Chromosome Location: Xp22
• Function: ATP binding; Rac GTPase binding; cyclin-dependent protein kinase activity; kinase activity; nucleotide binding; protein kinase activity; protein serine/threonine kinase activity