Recombinant Human CDK8, His-tagged

• Cat.No.: CDK8-09H
• Product Overview: Recombinant human CDK8 fused to 6*His tag with the vector PET28a was expressed in E. coli.

Specification

• Species: Human
• Source: E.coli
• Tag: His
• Description: The protein encoded by this gene is a member of the cyclin-dependent protein kinase (CDK) family. CDK family members are highly similar to the gene products of Saccharomyces cerevisiae cdc28, and Schizosaccharomyces pombe cdc2, and are known to be important regulators of cell cycle progression. This kinase and its regulatory subunit cyclin C are components of the RNA polymerase II holoenzyme complex, which phosphorylates the carboxy-terminal domain (CTD) of the largest subunit of RNA polymerase II. This kinase has also been shown to regulate transcription by targeting the CDK7/cyclin H subunits of the general transcription initiation factor IIH (TFIIH), thus providing a link between the 'Mediator-like' protein complexes and the basal transcription machinery.
• Antigen Peptide Region: C-105aa
• Storage Buffer: 1M PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8.0) added with 300mM Imidazole and 0.7% Sarcosyl, 15% glycerol.
• OfficialSymbol: CDK8

Gene Information

• Gene Name: CDK8 cyclin-dependent kinase 8 [ Homo sapiens ]
• Synonyms: CDK8; cyclin-dependent kinase 8; K35; protein kinase K35; CDK8 protein kinase; mediator complex subunit CDK8; cell division protein kinase 8; mediator of RNA polymerase II transcription subunit CDK8; Cell division protein kinase 8; Mediator of RNA polymerase II transcription subunit CDK8; Protein kinase K35; EC 2.7.11.22; EC 2.7.11.23; EC 2.7.11
• Gene ID: 1024
• mRNA Refseq: NM_001260
• Protein Refseq: NP_001251
• MIM: 603184
• UniProt ID: P49336
• Chromosome Location: 13q12
• Pathway: Developmental Biology; Fatty acid; Gene Expression
• Function: ATP binding; RNA polymerase II carboxy-terminal domain kinase activity; cyclin-dependent protein kinase activity