Recombinant Human CDK2AP1, His-tagged

• Cat.No.: CDK2AP1-27911TH
• Product Overview: Recombinant full length Human CDKA1 / DOC1 fused to His tag at N-terminus; amino acids 1-115 , 16.6kDa.

Specification

• Description: The protein encoded by this gene is a specific CDK2-associated protein, which is thought to negatively regulate CDK2 activity by sequestering monomeric CDK2, and targeting CDK2 for proteolysis. This protein was found to also interact with DNA polymerase alpha/primase and mediate the phosphorylation of the large p180 subunit, which suggested the regulatory role in DNA replication during S phase of the cell cycle. A similar gene in hamster was isolated from, and functions as a growth suppressor of normal keratinocytes.
• Conjugation: HIS
• Source: E. coli
• Form: Liquid
• Purity: >95% by SDS-PAGE
• Storage buffer: Preservative: NoneConstituents: 50% Glycerol, 20mM Tris HCl, 2mM DTT, pH 8.0
• Storage: Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
• Sequences of amino acids: MRGSHHHHHH GMASMTGGQQ MGRDLYDDDD KDRWGSHMSY KPNLAAHMPA AALNAAGSVH SPSTSMATSS QYRQLLSDYG PPSLGYTQGT GNSQVPQSKY AELLAIIEEL GKEIRPTYAG SKSAMERLKR GIIHARGLVR ECLAETERNA RS
• Sequence Similarities: Belongs to the CDK2AP family.
• Protein length: 1-115 a.a.
• Full Length: Full L.

Gene Information

• Gene Name: CDK2AP1 cyclin-dependent kinase 2 associated protein 1 [ Homo sapiens ]
• Official Symbol: CDK2AP1
• Synonyms: CDK2AP1; cyclin-dependent kinase 2 associated protein 1; CDK2 associated protein 1; cyclin-dependent kinase 2-associated protein 1; doc 1; DOC1; DORC1; p12DOC 1; ST19
• Gene ID: 8099
• mRNA Refseq: NM_004642
• Protein Refseq: NP_004633
• MIM: 602198
• Uniprot ID: O14519
• Chromosome Location: 12q24
• Function: DNA binding