CDK2AP1
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Official Full Name
cyclin-dependent kinase 2 associated protein 1 -
Overview
The protein encoded by this gene is a specific CDK2-associated protein, which is thought to negatively regulate CDK2 activity by sequestering monomeric CDK2, and targeting CDK2 for proteolysis. This protein was found to also interact with DNA polymerase alpha/primase and mediate the phosphorylation of the large p180 subunit, which suggested the regulatory role in DNA replication during S phase of the cell cycle. A similar gene in hamster was isolated from, and functions as a growth suppressor of normal keratinocytes. -
Synonyms
CDK2AP1;cyclin-dependent kinase 2 associated protein 1;CDK2 associated protein 1;cyclin-dependent kinase 2-associated protein 1;doc 1;DOC1;DORC1;p12DOC 1;ST19;CDK2 A1;CDK2-associated protein 1;CDKA1;CDKA1_HUMAN;Cyclin dependent kinase 2 associated protein 1;Deleted in oral cancer 1;DOC 1 related protein;DOC 1R;DOC-1;DOC1R;Putative oral cancer suppressor;OTTHUMP00000239636;OTTHUMP00000239637;OTTHUMP00000239638;OTTHUMP00000239639;OTTHUMP00000239640;Deleted in oral cancer-1;p12DOC-1
Recombinant Proteins
- Human
- Mouse
- Chicken
- E.coli
- Wheat Germ
- Mammalian Cell
- HEK293
- Mammalian cells
- HEK293T
- In Vitro Cell Free System
- GST
- His
- Non
- His&Fc&Avi
- Myc&DDK
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| CDK2AP1-11047H | Recombinant Human CDK2AP1, GST-tagged | E.coli | Human | GST | 1-115a.a. | |
| CDK2AP1-1005H | Recombinant Human CDK2AP1 Protein, GST-Tagged | Wheat Germ | Human | GST |
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| CDK2AP1-1936H | Recombinant Human CDK2AP1, His-tagged | E.coli | Human | His |
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| CDK2AP1-27910TH | Recombinant Human CDK2AP1, His-tagged | E.coli | Human | His | 115 amino acids |
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| CDK2AP1-27911TH | Recombinant Human CDK2AP1, His-tagged | E.coli | Human | His | Full L. 1-115 a.a. |
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| CDK2AP1-3201M | Recombinant Mouse CDK2AP1 Protein | Mammalian Cell | Mouse | His |
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| CDK2AP1-3329C | Recombinant Chicken CDK2AP1 | Mammalian Cell | Chicken | His |
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| CDK2AP1-7628HCL | Recombinant Human CDK2AP1 293 Cell Lysate | HEK293 | Human | Non |
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| CDK2AP1-0977H | Recombinant Human CDK2AP1 Protein (Met1-Ser115), C-His tagged | Mammalian cells | Human | His | Met1-Ser115 |
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| CDK2AP1-1086H | Recombinant Human CDK2AP1 Protein (Met1-Ser115), N-GST tagged | E.coli | Human | GST | Met1-Ser115 |
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| CDK2AP1-1523M | Recombinant Mouse CDK2AP1 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| CDK2AP1-1523M-B | Recombinant Mouse CDK2AP1 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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| Cdk2ap1-2088M | Recombinant Mouse Cdk2ap1 Protein, Myc/DDK-tagged | HEK293T | Mouse | Myc&DDK |
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| CDK2AP1-3179HF | Recombinant Full Length Human CDK2AP1 Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 115 amino acids |
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| CDK2AP1-5275H | Recombinant Human CDK2AP1 Protein, Myc/DDK-tagged, C13 and N15-labeled | HEK293T | Human | Myc&DDK |
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Involved Pathway
CDK2AP1 involved in several pathways and played different roles in them. We selected most pathways CDK2AP1 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with CDK2AP1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
Protein Function
CDK2AP1 has several biochemical functions, for example, DNA polymerase binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CDK2AP1 itself. We selected most functions CDK2AP1 had, and list some proteins which have the same functions with CDK2AP1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | RNF220,TECPR1,PCBP1,TRIM17,RET,ALOX5AP,ZFYVE16,GRAMD3,COMMD8,PIAS3 |
| DNA polymerase binding | HMGB1,LONP1,RAD51,ACD,FANCD2,SMARCA4,FANCI,PCNA |
Interacting Protein
CDK2AP1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CDK2AP1 here. Most of them are supplied by our site. Hope this information will be useful for your research of CDK2AP1.
MRFAP1L1;HDAC1;HDAC2;CCDC136;MTA2;MBD3
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