Description :	The constitutively active form of human Cdc42 protein contains a glutamine to leucine substitution at residue 61. The common name for this mutant is Cdc42(Q61L) or L61Cdc42. The leucine substitution prevents endogenous and GAP-stimulated GTPase activity of Cdc42, hence the protein is always in the active, GTP-bound, state. A similar mutation in Ras (Ras(Q61L)) behaves as an oncogenic mutation.
Source :	E. coli
Species :	Human
Tag :	His
Form :	2 mM Tris pH 7.6, 0.5 mM MgCl2, 0.5% sucrose and 0.1% dextran.
Molecular Mass :	~25 kDa
Purity :	>70% pure
Applications :	Cdc42 effector and GAP identification and binding studies; Activation of Cdc42 effectors in vitro and in vivo; Stimulation of Cdc42 phenotype by microinjection into cells

Gene Name	CDC42 cell division cycle 42 (GTP binding protein, 25kDa) [ Homo sapiens ]
Official Symbol	CDC42
Synonyms	CDC42; cell division cycle 42 (GTP binding protein, 25kDa); cell division cycle 42 (GTP binding protein, 25kD); cell division control protein 42 homolog; CDC42Hs; G25K; G25K GTP-binding protein; GTP-binding protein, 25kD; growth-regulating protein; small GTP binding protein CDC42; dJ224A6.1.1 (cell division cycle 42 (GTP-binding protein, 25kD)); dJ224A6.1.2 (cell division cycle 42 (GTP-binding protein, 25kD));
Gene ID	998
mRNA Refseq	NM_001039802
Protein Refseq	NP_001034891
MIM	116952
UniProt ID	P60953
Chromosome Location	1p36.1
Pathway	Adaptive Immune System, organism-specific biosystem; Adherens junction, organism-specific biosystem; Adherens junction, conserved biosystem; Axon guidance, organism-specific biosystem; Axon guidance, conserved biosystem; Axon guidance, organism-specific biosystem; Axon guidance, organism-specific biosystem;
Function	GTP binding; GTP-dependent protein binding; GTPase activity; GTPase activity; mitogen-activated protein kinase kinase kinase binding; nucleotide binding; protein binding; thioesterase binding;