Recombinant Human CDC42 Binding Protein Kinase Alpha (DMPK-like), His-tagged

• Cat.No.: CDC42BPA-368H
• Product Overview: Recombinanthuman CDC42BPA, catalytic domain (amino acids 1-473) with His Tag.

Specification

• Species: Human
• Source: Insect Cells
• Tag: His
• Protein Length: 1-473 a.a.
• Description: Theprotein encoded by this gene is a member of the Serine/Threonine proteinkinase family. This kinase contains multiple functional domains. Its kinasedomain is highly similar to that of the myotonic dystrophy protein kinase(DMPK). This kinase also contains a Rac interactive binding (CRIB) domain,and has been shown to bind CDC42. It may function as a CDC42 downstreameffector mediating CDC42 induced peripheral actin formation, and promotingcytoskeletal reorganization. Multiple alternatively spliced transcriptvariants have been described, and the full-length nature of two of them hasbeen reported.
• Form: Liquid in50 mM Tris, pH 7.5 + 150 mM NaCl + 0.5 mM EDTA + 0.02% Triton X-100 + 2 mMDTT + 50% glycerol.
• Molecular Weight: 58.7 kDa
• Purity: ≥ 90% asdetermined by a Coomassie blue-stained SDS-PAGE gel.
• Specific Activity: 179 nmoleof phosphate transferred to S6 peptide substrate (AKRRRLSSLRA) per minute permg of total protein at 30°C. Activity determined at a final protein concentrationof 3.33 ug/ml.
• Storage: Stablefor 6 months in working aliquots at -80°C. Avoid repeated freeze-thaw cycles.
• OfficialSymbol: CDC42BPA

Gene Information

• Gene Name: CDC42BPACDC42 binding protein kinase alpha (DMPK-like) [ Homo sapiens ]
• Synonyms: CDC42BPA;CDC42 binding protein kinase alpha (DMPK-like); MRCK; MRCKA; PK428;FLJ23347; KIAA0451; DKFZp686L1738; DKFZp686P1738; CDC42-bindingprotein kinase alpha (DMPK-like); OTTHUMP00000035727; OTTHUMP00000035728; OTTHUMP00000035729;OTTHUMP00000035730; OTTHUMP00000035731; OTTHUMP00000035732; OTTHUMP00000035733;Serine/threonine-proteinkinase MRCK alpha; EC 2.7.11.1; CDC42-binding protein kinasealpha; DMPK-like alpha; Myotonic dystrophy kinase-related CDC42-binding kinasealpha; ser-thr protein kinaserelated to the myotonic dystrophy protein kinase
• Gene ID: 8476
• mRNA Refseq: NM_003607
• Protein Refseq: NP_003598
• MIM: 603412
• UniProt ID: Q5VT25
• Chromosome Location: 1q42.11
• Pathway: CDC42 signalingevents
• Function: protein binding; ATPbinding; identical protein binding; magnesium ion binding; nucleotidebinding; protein serine/threoninekinase activity; small GTPase regulator activity