Recombinant Human CDC37, GST-tagged

• Cat.No.: CDC37-11006H
• Product Overview: Recombinant Human CDC37 protein, fused to GST-tag, was expressed in E.coli and purified by GSH-sepharose.

Specification

• Description: The protein encoded by this gene is expressed only in Langerhans cells which are immature dendritic cells of the epidermis and mucosa. It is localized in the Birbeck granules, organelles present in the cytoplasm of Langerhans cells and consisting of superimposed and zippered membranes. It is a C-type lectin with mannose binding specificity, and it has been proposed that mannose binding by this protein leads to internalization of antigen into Birbeck granules and providing access to a nonclassical antigen-processing pathway. Mutations in this gene result in Birbeck granules deficiency or loss of sugar binding activity.
• Source: E.coli
• Species: Human
• Tag: GST
• Protein length: 1-209a.a.
• Storage: The protein is stored in PBS buffer at -20℃. Avoid repeated freezing and thawing cycles.
• Storage Buffer: 1M PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8. ) added with 100mM GSH and 1% Triton X-100,15%glycerol.

Gene Information

• Gene Name: CDC37 cell division cycle 37 homolog (S. cerevisiae) [ Homo sapiens ]
• Official Symbol: CDC37
• Synonyms: CDC37; cell division cycle 37 homolog (S. cerevisiae); CDC37 (cell division cycle 37, S. cerevisiae, homolog) , CDC37 cell division cycle 37 homolog (S. cerevisiae); hsp90 co-chaperone Cdc37; CDC37 (cell division cycle 37; S. cerevisiae; homolog); CDC37 cell division cycle 37 homolog; Hsp90 co chaperone Cdc37; P50CDC37; hsp90 chaperone protein kinase-targeting subunit; CDC37 (cell division cycle 37, S. cerevisiae, homolog)
• Gene ID: 11140
• mRNA Refseq: NM_007065
• Protein Refseq: NP_008996
• MIM: 605065
• UniProt ID: Q16543
• Chromosome Location: 19p13.2
• Pathway: Androgen Receptor Signaling Pathway, organism-specific biosystem; Disease, organism-specific biosystem; LKB1 signaling events, organism-specific biosystem; Signal Transduction, organism-specific biosystem; Signaling by EGFR in Cancer, organism-specific biosystem; Signaling by ERBB2, organism-specific biosystem; Signaling by constitutively active EGFR, organism-specific biosystem
• Function: Hsp90 protein binding; heat shock protein binding; protein binding; protein kinase binding; unfolded protein binding