Recombinant Human CDC34, His-tagged

• Cat.No.: CDC34-26224TH
• Product Overview: Recombinant full length Human Cdc34 with His tag, 32kDa.

Specification

• Description: The protein encoded by this gene is a member of the ubiquitin-conjugating enzyme family. Ubiquitin-conjugating enzyme catalyzes the covalent attachment of ubiquitin to other proteins. This protein is a part of the large multiprotein complex, which is required for ubiquitin-mediated degradation of cell cycle G1 regulators, and for the initiation of DNA replication.
• Protein length: 236 amino acids
• Conjugation: HIS
• Molecular Weight: 32.000kDa inclusive of tags
• Source: E. coli
• Tissue specificity: Expressed in testes during spermatogenesis to regulate repression of cAMP-induced transcription.
• Form: Liquid
• Purity: >95% by SDS-PAGE
• Storage buffer: pH: 8.00Constituents:1.2% HEPES, 0.292% Sodium chloride, 0.02% DTT
• Storage: Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles.
• Sequence Similarities: Belongs to the ubiquitin-conjugating enzyme family.

Gene Information

• Gene Name: CDC34 cell division cycle 34 homolog (S. cerevisiae) [ Homo sapiens ]
• Official Symbol: CDC34
• Synonyms: CDC34; cell division cycle 34 homolog (S. cerevisiae); cell division cycle 34; ubiquitin-conjugating enzyme E2 R1; E2 CDC34; UBC3; UBE2R1
• Gene ID: 997
• mRNA Refseq: NM_004359
• Protein Refseq: NP_004350
• MIM: 116948
• Uniprot ID: P49427
• Chromosome Location: 19p13.3
• Pathway: Adaptive Immune System, organism-specific biosystem; Antigen processing: Ubiquitination & Proteasome degradation, organism-specific biosystem; Class I MHC mediated antigen processing & presentation, organism-specific biosystem
• Function: ATP binding; acid-amino acid ligase activity; ligase activity; nucleotide binding; protein binding