Recombinant Human CDC27, GST-tagged

• Cat.No.: CDC27-11003H
• Product Overview: Recombinant Human CDC27 protein, fused to GST-tag, was expressed in E.coli and purified by GSH-sepharose.

Specification

• Species: Human
• Source: E.coli
• Tag: GST
• Protein Length: C-term-350a.a.
• Description: This gene encodes a member of the CD1 family of transmembrane glycoproteins, which are structurally related to the major histocompatibility complex (MHC) proteins and form heterodimers with beta-2-microglobulin. The CD1 proteins mediate the presentation of primarily lipid and glycolipid antigens of self or microbial origin to T cells. The human genome contains five CD1 family genes organized in a cluster on chromosome 1. The CD1 family members are thought to differ in their cellular localization and specificity for particular lipid ligands. The protein encoded by this gene localizes to late endosomes and lysosomes via a tyrosine-based motif in the cytoplasmic tail, and requires vesicular acidification to bind lipid antigens.
• Storage: The protein is stored in PBS buffer at -20℃. Avoid repeated freezing and thawing cycles.
• Storage Buffer: 1M PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8. ) added with 100mM GSH and 1% Triton X-100,15%glycerol.

Gene Information

• Gene Name: CDC27 cell division cycle 27 homolog (S. cerevisiae) [ Homo sapiens ]
• Official Symbol: CDC27
• Synonyms: CDC27; cell division cycle 27 homolog (S. cerevisiae); cell division cycle 27 , D17S978E, D0S1430E; cell division cycle protein 27 homolog; ANAPC3; anaphase promoting complex subunit 3; APC3; NUC2; H-NUC; nuc2 homolog; CDC27 homolog; anaphase-promoting complex subunit 3; anaphase-promoting complex, protein 3; HNUC; CDC27Hs; D0S1430E; D17S978E
• Gene ID: 996
• mRNA Refseq: NM_001114091
• Protein Refseq: NP_001107563
• MIM: 116946
• UniProt ID: P30260
• Chromosome Location: 17q21.32
• Pathway: APC/C complex, organism-specific biosystem; APC/C complex, conserved biosystem; APC/C-mediated degradation of cell cycle proteins, organism-specific biosystem; APC/C:Cdc20 mediated degradation of Cyclin B, organism-specific biosystem; APC/C:Cdc20 mediated degradation of Securin, organism-specific biosystem; APC/C:Cdc20 mediated degradation of mitotic proteins, organism-specific biosystem; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1, organism-specific biosystem
• Function: protein binding; protein phosphatase binding