CDC27
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Official Full Name
CDC27 cell division cycle 27 homolog (S. cerevisiae) -
Overview
The protein encoded by this gene shares strong similarity with Saccharomyces cerevisiae protein Cdc27, and the gene product of Schizosaccharomyces pombe nuc 2. This protein is a component of anaphase-promoting complex (APC), which is composed of eight protein subunits and highly conserved in eucaryotic cells. APC catalyzes the formation of cyclin B-ubiquitin conjugate that is responsible for the ubiquitin-mediated proteolysis of B-type cyclins. This protein and 3 other members of the APC complex contain the TPR (tetratricopeptide repeat), a protein domain important for protein-protein interaction. This protein was shown to interact with mitotic checkpoint proteins including Mad2, p55CDC and BUBR1, and thus may be involved in controlling the timing of mitosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. -
Synonyms
CDC27;cell division cycle 27 homolog (S. cerevisiae);APC3;HNUC;NUC2;ANAPC3;CDC27Hs;D0S1430E;D17S978E;cell division cycle protein 27 homolog;H-NUC;nuc2 homolog;CDC27 homolog;OTTHUMP00000232872;OTTHUMP00000232873;OTTHUMP00000232875;OTTHUMP00000232877;anaphase promoting complex subunit 3;anaphase-promoting complex subunit 3;anaphase-promoting complex, protein 3
Recombinant Proteins
- Human
- Zebrafish
- Rat
- Chicken
- Mouse
- E.coli
- Wheat Germ
- Mammalian Cell
- HEK293
- In Vitro Cell Free System
- GST
- His
- His&T7
- Non
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| CDC27-11003H | Recombinant Human CDC27, GST-tagged | E.coli | Human | GST | C-term-350a.a. | |
| CDC27-3589H | Recombinant Human CDC27 protein, His-tagged | E.coli | Human | His | 481-830 aa | |
| CDC27-0920H | Recombinant Human CDC27 Protein, GST-Tagged | Wheat Germ | Human | GST |
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| CDC27-11496Z | Recombinant Zebrafish CDC27 | Mammalian Cell | Zebrafish | His |
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| CDC27-1271H | Recombinant Human CDC27 protein, His & T7-tagged | E.coli | Human | His&T7 | Asn17~Ser231 |
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| CDC27-1274R | Recombinant Rat CDC27 Protein | Mammalian Cell | Rat | His |
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| CDC27-1475C | Recombinant Chicken CDC27 | Mammalian Cell | Chicken | His |
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| CDC27-3135M | Recombinant Mouse CDC27 Protein | Mammalian Cell | Mouse | His |
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| CDC27-7662HCL | Recombinant Human CDC27 293 Cell Lysate | HEK293 | Human | Non |
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| CDC27-0704H | Recombinant Human CDC27 Protein (Asn17-Ser231), N-His tagged | E.coli | Human | His | Asn17-Ser231 |
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| CDC27-1481M | Recombinant Mouse CDC27 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| CDC27-1481M-B | Recombinant Mouse CDC27 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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| CDC27-3071HF | Recombinant Full Length Human CDC27 Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 830 amino acids |
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| CDC27-932R | Recombinant Rat CDC27 Protein, His (Fc)-Avi-tagged | HEK293 | Rat | His&Fc&Avi |
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| CDC27-932R-B | Recombinant Rat CDC27 Protein Pre-coupled Magnetic Beads | HEK293 | Rat |
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Involved Pathway
CDC27 involved in several pathways and played different roles in them. We selected most pathways CDC27 participated on our site, such as Cell cycle,Oocyte meiosis,Ubiquitin mediated proteolysis, which may be useful for your reference. Also, other proteins which involved in the same pathway with CDC27 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Ubiquitin mediated proteolysis | CBL,CUL3A,PPIL2,ITCH,CUL1B,UBE2D4,FBXW8,BIRC8,UBE4B,XIAP |
| Progesterone-mediated oocyte maturation | PIK3CB,CDC23,PGR,IGF1RB,CPEB4,GNAI3,PLK1,CDK1,FZR1A,MAPK12 |
| Cell cycle | GADD45A,ODF2B,SKA2,DBF4,BABAM1,GSK3AA,CENPO,CENPK,SMC3,CENPH |
| Oocyte meiosis | SGOL1,SKP1,CAMK2D,ANAPC5,PPP2R5CB,CUL1,IGF1RB,PPP1CC,RBX1,RPS6KA3A |
| HTLV-I infection | TNF,TP53INP1,POLB,WNT4,MYBL2,IL2RG,PPP3R1,LCK,IL1R1,PIK3R3 |
Protein Function
CDC27 has several biochemical functions, for example, protein binding,protein phosphatase binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CDC27 itself. We selected most functions CDC27 had, and list some proteins which have the same functions with CDC27. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein phosphatase binding | STAT3,SNX3,PPP6R1,ITPR1,VCAN,JAK3,KAT2A,HSP90B1,MAPK14,IRS2 |
| protein binding | KLRB1F,HIRIP3,ZNF622,PIDD1,MX2,HILPDA,IARS,ABCD2,GZMA,KCTD13 |
Interacting Protein
CDC27 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CDC27 here. Most of them are supplied by our site. Hope this information will be useful for your research of CDC27.
CDC20;FZR1;BUB1B;CDC16
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References
- Kraft, C; Herzog, F; et al. Mitotic regulation of the human anaphase-promoting complex by phosphorylation. EMBO JOURNAL 22:6598-6609(2003).
- Tokumoto, T; Tokumoto, M; et al. Purification of anaphase promoting complex/cyclosome from goldfish oocytes. FISH PHYSIOLOGY AND BIOCHEMISTRY 28:371-371(2003).
