Recombinant Human CD274 Molecule, His-tagged

• Cat.No.: CD274-6775H
• Product Overview: Recombinant humanCD274 protein, fused to His-tag at N-terminus, was expressed in E.coli andpurified by using conventional chromatography.

Specification

• Cat. No.: CD274-6775H
• Description: CD274, also known asprogrammed cell death 1 ligand 1(PDCD1L1), is involved in the costimulatorysignal, essential for T-cell proliferation and production of IL10 and IFNG,in an IL2-dependent and a PDCD1-independent manner. This protein interactionwith PDCD1 inhibits T-cell proliferation and cytokine production.
• Form: Liquid. 20mMTris-HCl buffer (pH8.0) containing 10% glycerol, 1mM DTT
• Molecular Weight: 27.9 kDa (245aa),confirmed by MALDI-TOF (Molecular weight on SDS-PAGE will appear higher)
• Purity: > 90% by SDS -PAGE
• Concentration: 1 mg/ml (determinedby Bradford assay)
• Sequences of aminoacids: MGSSHHHHHHSSGLVPRGSH MGSHMFTVTV PKDLYVVEYG SNMTIECKFP VEKQLDLAAL IVYWEMEDKN IIQFVHGEEDLKVQHSSYRQ RARLLKDQLS LGNAALQITD VKLQDAGVYR CMISYGGADY KRITVKVNAP YNKINQRILVVDPVTSEHEL TCQAEGYPKA EVIWTSSDHQ VLSGKTTTTN SKREEKLFNV TSTLRINTTT NEIFYCTFRRLDPEENHTAE LVIPELPLAH PPNER
• Storage: Can be stored at+4°C short term (1-2 weeks). For long term storage, aliquot and store at-20°C or -70°C. Avoid repeated freezing and thawing cycles.

Gene Information

• Gene Name: CD274CD274 molecule [ Homo sapiens ]
• Official symbol: CD274
• Synonyms: CD274; CD274 molecule; B7-H; B7H1;PDL1; PD-L1; PDCD1L1; PDCD1LG1; MGC142294; MGC142296; programmed cell death 1ligand 1; CD274 antigen; Programmed cell death 1 ligand 1; Programmed deathligand 1; PDCD1 ligand 1; B7 homolog 1; OTTHUMP00000021029
• Gene ID: 29126
• mRNA Refseq: NM_014143
• Protein Refseq: NP_054862
• MIM: 605402
• UniProt ID: Q9NZQ7
• Chromosome Location: 9q24.1
• Pathway: Cell adhesion molecules (CAMs);Signaling in Immune system
• Function: protein binding; receptor activity