Active Recombinant Human CD274, HIgG1 Fc-tagged
| Cat.No. : | CD274-020H |
| Product Overview : | The extracellular domain of human PDL1 (NP_054862.1) ( Phe19-Arg238) is fused to the N-terminus of the Fc region of human IgG1 was expressed in CHO cell. |
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| Description : | CD274 (CD274 molecule) is a protein-coding gene. Diseases associated with CD274 include pulmonary venoocclusive disease, and htlv-1 associated myelopathy/tropical spastic paraparesis, and among its related super-pathways are Immune System and Phosphorylation of CD3 and TCR zeta chains. GO annotations related to this gene include protein binding |
| Source : | CHO cells |
| Species : | Human |
| Tag : | HIgG1 Fc-tagged |
| Form : | Lyophilized from 0.2μm-filtered solution in PBS. |
| Bio-activity : | Measured by its ability to inhibit anti-CD3 antibody induced IL-2 secretion in human T lymphocytes. |
| Molecular Mass : | 54 KDa (monomer) |
| AA Sequence : | Phe19-Arg238 |
| Endotoxin : | <0.06 eu/μg="" as="" determined="" by="" lal="" test.=""> |
| Purity : | >98%, by SDS-PAGE under reducing conditions. |
| Stability : | Stable for at least 1 year after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C. |
| Reconstitution : | Reconstitute at 100μg/ml in sterile PBS. |
| Warning : | Avoid freeze/thaw cycles. |
| Protein length : | 19-238 a.a. |
| Gene Name | CD274 CD274 molecule [ Homo sapiens ] |
| Official Symbol | CD274 |
| Synonyms | CD274; CD274 molecule; CD274 antigen , PDCD1LG1, programmed cell death 1 ligand 1; programmed cell death 1 ligand 1; B7 homolog 1; B7 H; B7 H1; B7H1; PD L1; PDL1; CD274 antigen; PDCD1 ligand 1; programmed death ligand 1; B7-H; PD-L1; PDCD1L1; PDCD1LG1; MGC142294; MGC142296; |
| Gene ID | 29126 |
| mRNA Refseq | NM_014143 |
| Protein Refseq | NP_054862 |
| MIM | 605402 |
| UniProt ID | Q9NZQ7 |
| Chromosome Location | 9p24.1 |
| Pathway | Adaptive Immune System, organism-specific biosystem; Cell adhesion molecules (CAMs), organism-specific biosystem; Cell adhesion molecules (CAMs), conserved biosystem; Costimulation by the CD28 family, organism-specific biosystem; Immune System, organism-specific biosystem; PD-1 signaling, organism-specific biosystem; |
| Function | protein binding; protein tyrosine phosphatase activity; receptor activity; |
Not For Human Consumption!
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