Recombinant Human CBL cell lysate

Description :	The cbl oncogene was first identified as part of a transforming retrovirus which induces mouse pre-B and pro-B cell lymphomas. As an adaptor protein for receptor protein-tyrosine kinases, it positively regulates receptor protein-tyrosine kinase ubiquitination in a manner dependent upon its variant SH2 and RING finger domains. Ubiquitination of receptor protein-tyrosine kinases terminates signaling by marking active receptors for degradation.
Species :	Human
Size :	100 ul
Storage Buffer :	1X Sample Buffer (50 mM Tris-HCl, 2% SDS, 10% glycerol, 300 mM 2-mercaptoethanol, 0.01% Bromophenol blue)
Applications :	Western Blot;
Tag :	Non

Gene Name	CBL Cbl proto-oncogene, E3 ubiquitin protein ligase [ Homo sapiens ]
Official Symbol	CBL
Synonyms	CBL; Cbl proto-oncogene, E3 ubiquitin protein ligase; Cas Br M (murine) ecotropic retroviral transforming sequence , CBL2; E3 ubiquitin-protein ligase CBL; c Cbl; oncogene CBL2; RNF55; proto-oncogene c-Cbl; RING finger protein 55; signal transduction protein CBL; casitas B-lineage lymphoma proto-oncogene; Cas-Br-M (murine) ecotropic retroviral transforming sequence; CBL2; NSLL; C-CBL;
Gene ID	867
mRNA Refseq	NM_005188
Protein Refseq	NP_005179
MIM	165360
UniProt ID	P22681
Chromosome Location	11q23.3-qter
Pathway	Adaptive Immune System, organism-specific biosystem; Antigen Activates B Cell Receptor Leading to Generation of Second Messengers, organism-specific biosystem; B Cell Receptor Signaling Pathway, organism-specific biosystem; Bacterial invasion of epithelial cells, organism-specific biosystem; Bacterial invasion of epithelial cells, conserved biosystem; CDC42 signaling events, organism-specific biosystem; Chronic myeloid leukemia, organism-specific biosystem;
Function	SH3 domain binding; calcium ion binding; ephrin receptor binding; ligase activity; phosphotyrosine binding; protein binding; sequence-specific DNA binding transcription factor activity; signal transducer activity; ubiquitin-protein ligase activity; zinc ion binding;