CBL
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Official Full Name
Cas-Br-M (murine) ecotropic retroviral transforming sequence -
Overview
The cbl oncogene was first identified as part of a transforming retrovirus which induces mouse pre-B and pro-B cell lymphomas. As an adaptor protein for receptor protein-tyrosine kinases, it positively regulates receptor protein-tyrosine kinase ubiquitination in a manner dependent upon its variant SH2 and RING finger domains. Ubiquitination of receptor protein-tyrosine kinases terminates signaling by marking active receptors for degradation. -
Synonyms
4732447J05Rik;C CBL;Cas Br M (murine) ecotropic retroviral transforming sequence;Cas-Br-M (murine) ecotropic retroviral transforming sequence;Casitas B lineage lymphoma proto oncogene;Casitas B-lineage lymphoma proto-oncogene;CBL 2;cbl;CBL_HUMAN;CBL2;E3 ubiquitin protein ligase CBL;E3 ubiquitin-protein ligase CBL;Oncogene CBL2;Proto oncogene c CBL;Proto-oncogene c-CBL;RGD1561386;RING finger protein 55;RNF55;Signal transduction protein CBL;OTTHUMP00000232087
Recombinant Proteins
- Human
- Zebrafish
- Mouse
- Chicken
- Rhesus macaque
- Arabidopsis Thaliana
- E.coli
- Wheat Germ
- Mammalian Cells
- HEK293
- In Vitro Cell Free System
- His
- GST
- Non
- Avi
- Fc
- SUMO
- DDK
- Myc
- Flag
Involved Pathway
CBL involved in several pathways and played different roles in them. We selected most pathways CBL participated on our site, such as ErbB signaling pathway,Ubiquitin mediated proteolysis,Endocytosis, which may be useful for your reference. Also, other proteins which involved in the same pathway with CBL were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Endocytosis | ARPC5LB,ARRB2,RUFY1,SMAD3,WASLB,CHMP2A,HSPA1A,ASAP1A,ZFYVE16,GRK4 |
| Bacterial invasion of epithelial cells | PIK3CG,SHC3,ELMO2,PXN,PIK3CA,CDC42,ELMO3,ITGA5,SHC2,SEPT11 |
| Pathways in cancer | ITGA2,PTK2,CXCL12,LAMA1,CTBP2,KRAS,LPAR2,TCEB1,PLCB3,MAPK10 |
| Proteoglycans in cancer | NRAS,Fzd4,ROCK2,CAV2,WNT9A,WNT5A,HPSE2,Fasl,TLR2,RPS6KB1 |
| Chronic myeloid leukemia | STAT5A,SHC1,TGFBR2,PIK3CG,CBLB,GRB2,PIK3R3,TGFBR1,SHC4,SOS1 |
| Ubiquitin mediated proteolysis | ITCH,SOCS1,UBE2NA,FBXW7,CUL4B,UBE2B,MDM2,UBE2F,RBX1,FBXW11B |
| ErbB signaling pathway | HBEGFB,PIK3R3B,ERBB2,NRG2B,MAP2K1,STAT5A,MAPK9,RPS6KB1B,CAMK2G,RPS6KB1 |
| T cell receptor signaling pathway | GRAPA,NFATC3,CBLC,VAV3,RAF1,IL4,PPP3CB,NFATC1,CD8B,NCK1 |
| Insulin signaling pathway | PRKACBB,PYGB,PIK3CD,EIF4E1C,GRB2,PTPRF,MAPK8,CBLC,PPP1CAA,SH2B2 |
Protein Function
CBL has several biochemical functions, for example, SH3 domain binding,calcium ion binding,ephrin receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CBL itself. We selected most functions CBL had, and list some proteins which have the same functions with CBL. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| SH3 domain binding | INPP5D,ADAM19,ELMO2,ADAM9,MAPK15,SH3BP5B,EVL,ABI2,FUT8,SH3BP2 |
| signal transducer activity | TAS2R109,ADCYAP1R1A,GNA13B,TAS2R140,MAPKAPK2B,OLFR50,MC5RA,GNG12,IRS1,UNC13B |
| ligase activity | RTCD1,MKRN3,RNF6,RNF31,RNF43,IRF2BP1,PRPF19,SMURF2,UBE2NA,HECW1 |
| phosphotyrosine binding | LDLRAP1,MAPK1,ACP2,SAMSN1,SHC1,CBLB,ZAP70,CBLC,STAP1,PTPN3 |
| ubiquitin-protein transferase activity | CBLB,RNF13,FBXL14,UBE2H,WWP1,CDC23,MUL1B,UBE2Q2,MIB1,RNF125 |
| ubiquitin protein ligase activity | HECTD3,TRIM72,LTN1,ITCH,UBE2U,UHRF2,G2E3,MED1,RNF222,SIAH1 |
| protein binding | NR2F1,VPS33A,NAPRT1,DDX23,PTPN12,AMHR2,TTC12,VSIG4,RGP1,SNX31 |
| transcription factor activity, sequence-specific DNA binding | NFIL3,IKZF3,ZFP628,HMG20A,ATF4,ZFP629,HSFY1,SNAPC2,HOMEZB,POU3F4 |
| calcium ion binding | SPARCL1,PCDHA2,TPO,PKD1L3,SYT17,NKD1,EHD3,MYLPF,DAG1,EHD1B |
Interacting Protein
CBL has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CBL here. Most of them are supplied by our site. Hope this information will be useful for your research of CBL.
SH3KBP1
CBL Related Signal Pathway
Resources
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References
- Cao, HJ; Zheng, LZ; et al. Src blockage by siRNA inhibits VEGF-induced vascular hyperpemeability and osteoclast activity - an in vitro mechanism study for preventing destructive repair of osteonecrosis. BONE 74:58-68(2015).
- Plani-Lam, JHC; Chow, TC; et al. PTPN21 exerts pro-neuronal survival and neuritic elongation via ErbB4/NRG3 signaling. INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY 61:53-62(2015).
