Recombinant Human CBL

• Cat.No.: CBL-26492TH
• Product Overview: Recombinant full length Human CBL protein with an N terminal proprietary tag; predicted mwt: 125.73 kDa inclusive of tag.

Specification

• Description: The cbl oncogene was first identified as part of a transforming retrovirus which induces mouse pre-B and pro-B cell lymphomas. As an adaptor protein for receptor protein-tyrosine kinases, it positively regulates receptor protein-tyrosine kinase ubiquitination in a manner dependent upon its variant SH2 and RING finger domains. Ubiquitination of receptor protein-tyrosine kinases terminates signaling by marking active receptors for degradation.
• Protein length: 906 amino acids
• Molecular Weight: 125.730kDa inclusive of tags
• Source: Wheat germ
• Form: Liquid
• Purity: Proprietary Purification
• Storage buffer: pH: 8.00Constituents:0.79% Tris HCl, 0.3% Glutathione
• Storage: Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles.
• Sequences of amino acids: MAGNVKKSSGAGGGSGSGGSGSGGLIGLMKDAFQPHHHHH HHLSPHPPGTVDKKMVEKCWKLMDKVVRLCQNPKLALKNS PPYILDLLPDTYQHLRTILSRYEGKMETLGENEYFRVFME NLMKKTKQTISLFKEGKERMYEENSQPRRNLTKLSLIFSH MLAELKGIFPSGLFQGDTFRITKADAAEFWRKAFGEKTIV PWKSFRQALHEVHPISSGLEAMALKSTIDLTCNDYISVFE FDIFTRLFQPWSSLLRNWNSLAVTHPGYMAFLTYDEVKAR LQKFIHKPGSYIFRLSCTRLGQWAIGYVTADGNILQTIPH NKPLFQALIDGFREGFYLFPDGRNQNPDLTGLCEPTPQDH IKVTQEQYELYCEMGSTFQLCKICAENDKDVKIEPCGHLM CTSCLTSWQESEGQGCPFCRCEIKGTEPIVVDPFDPRGSG SLLRQGAEGAPSPNYDDDDDERADDTLFMMKELAGAKVER PPSPFSMAPQASLPPVPPRLDLLPQRVCVPSSASALGTAS KAASGSLHKDKPLPVPPTLRDLPPPPPPDRPYSVGAESRP QRRPLPCTPGDCPSRDKLPPVPSSRLGDSWLPRPIPKVPV SAPSSSDPWTGRELTNRHSLPFSLPSQMEPRPDVPRLGST FSLDTSMSMNSSPLVGPECDHPKIKPSSSANAIYSLAARP LPVPKLPPGEQCEGEEDTEYMTPSSRPLRPLDTSQSSRAC DCDQQIDSCTYEAMYNIQSQAPSITESSTFGEGNLAAAHA NTGPEESENEDDGYDVPKPPVPAVLARRTLSDISNASSSF GWLSLDGDPTTNVTEGSQVPERPPKPFPRRINSERKAGSC QQGSGPAASAATASPQLSSEIENLMSQGYSYQDIQKALVI AQNNIEMAKNILREFVSISSPAHVAT
• Sequence Similarities: Contains 1 Cbl-PTB (Cbl-type phosphotyrosine-binding) domain.Contains 1 RING-type zinc finger.Contains 1 UBA domain.
• Tag: Non

Gene Information

• Gene Name: CBL Cas-Br-M (murine) ecotropic retroviral transforming sequence [ Homo sapiens ]
• Official Symbol: CBL
• Synonyms: CBL; Cas-Br-M (murine) ecotropic retroviral transforming sequence; CBL2; E3 ubiquitin-protein ligase CBL; c Cbl; oncogene CBL2; RNF55
• Gene ID: 867
• mRNA Refseq: NM_005188
• Protein Refseq: NP_005179
• MIM: 165360
• Uniprot ID: P22681
• Chromosome Location: 11q23.3-qter
• Pathway: B Cell Receptor Signaling Pathway, organism-specific biosystem; Bacterial invasion of epithelial cells, organism-specific biosystem; Bacterial invasion of epithelial cells, conserved biosystem; CDC42 signaling events, organism-specific biosystem; Chronic myeloid leukemia, organism-specific biosystem
• Function: SH3 domain binding; calcium ion binding; ephrin receptor binding; ligase activity; phosphotyrosine binding