Recombinant Human Cathepsin S

Cat. No. :	CTSS-750H
Description :	A major lysosomal cysteine proteinase that is preferentially expressed in macrophages and microglia. Shown to be involved in the processing of antigenic peptides for presentation by MHC Class II molecules on the surface of antigen-presenting cells by mediating invariant (Ii) chain degradation. Inhibition of cathepsin S results in impaired antigen-presentation.
Source :	E.coli.
Purity :	≥90% by SDS-PAGE.
Form :	Liquid. In 35 mM potassium phosphate, 35 mM Sodium acetate, 2 mM DTT, 2 mM EDTA, 50% ethylene glycol, pH 6.5.
Specific Activity :	≥30,000 mU/mg protein.
Unit Definition :	One unit is defined as the amount of enzyme that will hydrolyze 1.0 µmol Z-VVR-AMC per min at 37°C, pH 6.5. Note: 1 mU = 1 milliunit.
Toxicity :	Harmful (MSDS available upon request).
Storage :	≤ -70℃. Avoid freeze/thaw. Following initial thaw, aliquot and freeze (-70℃).
Tag :	Non

Gene Name	CTSS cathepsin S [ Homo sapiens ]
Synonyms	CTSS; cathepsin S; MGC3886; Cathepsin S;EC 3.4.22.27; OTTHUMP00000032942
Gene ID	1520
mRNA Refseq	NM_004079
Protein Refseq	NP_004070
MIM	116845
UniProt ID	P25774
Chromosome Location	1q21
Pathway	Antigen processing and presentation; Lysosome
Function	cysteine-type endopeptidase activity; peptidase activity