Native Human cathepsin S

• Cat.No.: CTSS-27405TH
• Product Overview: Full length native Human Cathepsin S purified from Human Spleen; amino acids 115-331, 217 amino acids, MWt 24 kDa.

Specification

• Description: The protein encoded by this gene, a member of the peptidase C1 family, is a lysosomal cysteine proteinase that may participate in the degradation of antigenic proteins to peptides for presentation on MHC class II molecules. The encoded protein can function as an elastase over a broad pH range in alveolar macrophages. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.
• Biological activity: Activity: Cathepsin S activity detected using Z-Val-Val-Arg-AMC
• Form: Lyophilised
• Purity: >95% by SDS-PAGE
• Storage buffer: Preservative: NoneConstituents: 100mM Sodium acetate, 1mM EDTA, pH 5.5
• Storage: Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
• Tag: Non
• Protein length: 115-331

Gene Information

• Gene Name: CTSS cathepsin S [ Homo sapiens ]
• Official Symbol: CTSS
• Synonyms: CTSS; cathepsin S
• Gene ID: 1520
• mRNA Refseq: NM_001199739
• Protein Refseq: NP_001186668
• MIM: 116845
• Uniprot ID: P25774
• Chromosome Location: 1q21
• Pathway: Adaptive Immune System, organism-specific biosystem; Antigen processing and presentation, organism-specific biosystem; Antigen processing and presentation, conserved biosystem; Antigen processing-Cross presentation, organism-specific biosystem; Class I MHC mediated antigen processing &
• Function: cysteine-type endopeptidase activity; peptidase activity

Reviews

11/01/2021

High catalytic efficiency, short time, saving time.

06/13/2021

The solubility is very good and can be easily dissolved in various buffers.

03/27/2021

Anti-pollution ability is very strong, not easy to be polluted.

Q&As

How can the function of CTSS proteins be studied by gene knockout or knockdown techniques?

The function of CTSS proteins can be studied through gene knockout or knockdown techniques, such as using techniques such as CRISPR-Cas9 or RNAi. These techniques can create cellular models of missing or reduced CTSS proteins to observe their effects on cell death, among other things.

How can I detect the expression level of CTSS protein?

Expression level of CTSS protein can be detected by immunohistochemistry, western blotting, and real-time quantitative PCR.

How is CTSS protein involved in the process of apoptosis?

CTSS proteins promote cell death by degrading proteins inside cells. During apoptosis, CTSS proteins degrade key proteins within cells, leading to cell death.

Are the interactions between CTSS proteins and other proteins regulated?

The interaction between CTSS proteins and other proteins is regulated by the formation of complexes or the regulation of signal transduction pathways. These interactions can be influenced by a variety of factors, such as ion concentrations, neurotransmitters, and growth factors.

What is the relationship between the expression level of CTSS protein and the occurrence and progression of diseases?

Some studies have shown that the expression level of CTSS protein may be associated with the onset and progression of certain diseases. For example, in some cancers, the expression level of the CTSS protein may change.

In which organelles is CTSS protein expressed?

It is mainly expressed in lysosomes, which is one of the major proteases in lysosomes.