Recombinant Human CAMK2A, GST-tagged, Active

• Cat.No.: CAMK2A-264H
• Product Overview: Recombinant full-length human CAMK2alpha was expressed inSf9cells using an N-terminal GST tag. MW = 74 kDa.

Specification

• Species: Human
• Source: Sf9 Cells
• Tag: GST
• Description: CAMK2α is a ser/thr protein kinase that is a member of the Ca2+/calmodulin-dependent protein kinase family. CAMK2α is abundant in the brain as a major constituent of the postsynaptic density and is required for hippocampal long-term potentiation (LTP) and spatial learning. In addition to its Ca2+/calmodulin-dependent activity, CAMK2α can undergo autophosphorylation, resulting in Ca2+/calmodulin-independent activity. The protein level of CAMK2α fluctuates during neuronal activity in cultured rat pup hippocampal neurons. The levels of CAMK2α increased with heightened neuronal activity.
• Sequence: Full-length.
• Applications: Kinase Assay, Western Blot.
• Storage And Stability: Store product at -70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Gene Information

• Gene Name: CAMK2A calcium/calmodulin-dependent protein kinase II alpha [ Homo sapiens ]
• Synonyms: CAMK2A; calcium/calmodulin-dependent protein kinase II alpha; CAMKA; KIAA0968; CaMKIINalpha; CaMK-II alpha subunitCaM-kinase II alpha chain; CaM kinase II alpha subunit; calcium/calmodulin-dependent protein kinase II alpha-B subunit; calcium/calmodulin-dependent protein kinase type II alpha chain; calcium/calmodulin-dependent protein kinase (CaM kinase) II alpha; EC 2.7.11.17; OTTHUMP00000165787; OTTHUMP00000165788; CaM kinase II subunit alpha; CaMK-II alpha subunit; CaMK-II subunit alpha; calcium/calmodulin-dependent protein kinase II alpha
• Gene ID: 815
• mRNA Refseq: NM_015981
• Protein Refseq: NP_057065
• MIM: 114078
• UniProt ID: Q9UQM7
• Chromosome Location: 5q32
• Pathway: Calcium signaling pathway; ErbB signaling pathway; Glioma; GnRH signaling pathway; Long-term potentiation; Melanogenesis; Neurotrophin signaling pathway; Olfactory transduction; Wnt signaling pathway
• Function: ATP binding; calmodulin binding; calmodulin-dependent protein kinase activity; nucleotide binding; transferase activity