CAMK2A
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Official Full Name
calcium/calmodulin-dependent protein kinase II alpha -
Overview
The product of this gene belongs to the serine/threonine protein kinases family, and to the Ca(2+)/calmodulin-dependent protein kinases subfamily. Calcium signaling is crucial for several aspects of plasticity at glutamatergic synapses. This calcium calmodulin-dependent protein kinase is composed of four different chains: alpha, beta, gamma, and delta. The alpha chain encoded by this gene is required for hippocampal long-term potentiation (LTP) and spatial learning. In addition to its calcium-calmodulin (CaM)-dependent activity, this protein can undergo autophosphorylation, resulting in CaM-independent activity. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Nov 2008] -
Synonyms
CAMK2A;calcium/calmodulin-dependent protein kinase II alpha;CAMKA;calcium/calmodulin-dependent protein kinase type II subunit alpha;CaMKIINalpha;CaMK-II alpha subunit;caMK-II subunit alpha;CaM-kinase II alpha chain;CaM kinase II alpha subunit;caM kinase II subunit alpha;calcium/calmodulin-dependent protein kinase II alpha-B subunit;calcium/calmodulin-dependent protein kinase type II alpha chain;calcium/calmodulin-dependent protein kinase (CaM kinase) II alpha
Recombinant Proteins
- Human
- Rat
- Zebrafish
- Mouse
- Chicken
- Insect Cells
- E.coli
- S.frugiperda
- Wheat Germ
- Mammalian Cell
- Insect Cell
- Sf9 Insect Cell
- HEK293
- In Vitro Cell Free System
- E. coli
- Mammalian cells
- HEK293T
- Insect (sf21)
- GST
- His
- Non
- His&T7
- His&Fc&Avi
- Flag
- Myc&DDK
Involved Pathway
CAMK2A involved in several pathways and played different roles in them. We selected most pathways CAMK2A participated on our site, such as ErbB signaling pathway,Calcium signaling pathway,cAMP signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with CAMK2A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Neurotrophin signaling pathway | GAB1,CAMK2G,BRAF,SHC2,ARHGDIB,NTRK2,PRKCD,CALM4,SHC1,MAP3K5 |
| ErbB signaling pathway | CAMK2G1,CBL,MAP2K4,MAPK3,PTK2AA,ELK1,ERBB3B,CAMK2B1,GSK3B,ERBB4A |
| Cholinergic synapse | FOS,CHRNA4,CREB3L1,KCNQ3,GNG12,CREB5,GNA11,KCNQ4,KCNJ6,ATF4 |
| Adrenergic signaling in cardiomyocytes | MYH15,ADRB3A,MAPK3,ADCY8,ATP2B1A,ADCY9,PPP2R2A,PPP2R1B,CACNB4A,ADRA1B |
| Proteoglycans in cancer | PTPN6,RHOA,WNT16,WNT9B,Ctsl,THBS1,MAPK1,PLAU,MSN,PRKCA |
| Circadian entrainment | GNB1,ITPR3,PRKCA,GNG4,MAPK1,PER1,KCNJ6,GNAQ,PRKG2,RPS6KA5 |
| cAMP signaling pathway | GNAI3,GRIN1,GRIA2,HTR1F,SUCNR1,ROCK2,ARAP3,PIK3R1,NFKBIA,MAPK9 |
| GnRH signaling pathway | CAMK2B1,HRASB,MAPK8B,MAP2K2,MAPK9,CALM1B,GRB2,CDC42,CALM3,GNRHR |
| Olfactory transduction | OR8A1,OLFR151,OR1L1,CNGA4,OR2F1,OLFR10,OLFR508,OLFR469,CNGA3,GNG13 |
Protein Function
CAMK2A has several biochemical functions, for example, ATP binding,calmodulin binding,calmodulin-dependent protein kinase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CAMK2A itself. We selected most functions CAMK2A had, and list some proteins which have the same functions with CAMK2A. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| kinase activity | CAMK1DB,EPHB3A,AKT1,TGFBR1B,JAK2A,NEK4,FGFR1B,CAMK2G1,PANK1A,NADKD1 |
| calmodulin-dependent protein kinase activity | SLC14A2,MYLK2,MKNK2A,MKNK2B,CAMK1,MAPKAPK2B,PTK2B,CAMK2D2,DCX,MKNK2 |
| ATP binding | KIF18A,SMYHC3,DALRD3,ITGB1BP3,MERTK,MAT2AL,AACS,MTHFD1B,FGFR4,GRK4 |
| protein homodimerization activity | PYCARD,HSD17B4,NR4A2,S100A6,ASNSD1,STK25,CRYBA1,CHMP3,RASGRP1,MTHFD1L |
| glutamate receptor binding | GRIN1,GRIN2A,PLCG1,SYNDIG1 |
| protein serine/threonine kinase activity | MAPKAPK5,PRKCE,MAPK6,PASK,PRKACBB,TSSK4,ACVR1B,CSNK1G2B,CAMK1DA,BCR |
| protein binding | ZFPM1,TUBGCP2,EIF4B,MRPS31,POLRMT,MUTED,GORASP1,TPM3,SLC6A3,CAV2 |
| calmodulin binding | EEA1,MYO1D,CAMSAP1L1,SPHK1,CNGA2,MAP2,PHKA2,CAMK1GA,MYH4,NRGN |
Interacting Protein
CAMK2A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CAMK2A here. Most of them are supplied by our site. Hope this information will be useful for your research of CAMK2A.
GRIN2B;ACTN1;CAMK2D;calcium(2+);PPM1F;fem-2;RCHY1;Ppm1f;HSP90AB1;NR2F6;CALM1;CAMK2B;SMAD2;DLG3;CHMP5
Resources
Research Area
Calcium-binding Proteins and Related MoleculesIntracellular Kinases in the Akt Pathway
CaM Kinases
Wnt Intracellular Signaling
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References
