Recombinant Human C6 protein, His/T7-tagged

• Cat.No.: C6-10552H
• Product Overview: Recombinant Human C6(Gln682~Ala934) fused with His/T7 tag at N-terminal was expressed in E. coli.

Specification

• Species: Human
• Source: E.coli
• Tag: His&T7
• Protein Length: Gln682~Ala934
• Description: This gene encodes a component of the complement cascade. The encoded protein is part of the membrane attack complex that can be incorporated into the cell membrane and cause cell lysis. Mutations in this gene are associated with complement component-6 deficiency. Transcript variants encoding the same protein have been described.
• Form: Supplied as lyophilized form in PBS, pH7.4, containing 5% trehalose, 0.01% sarcosyl.
• Molecular Mass: 31.9kDa
• AA Sequence: MGSSHHHHHH SSGLVPRGSH MASMTGGQQM GRGS- QYFRCLPDG TWRQGDVECQ RTECIKPVVQ EVLTITPFQR LYRIGESIEL TCPKGFVVAG PSRYTCQGNS WTPPISNSLT CEKDTLTKLK GHCQLGQKQS GSECICMSPE EDCSHHSEDL CVFDTDSNDY FTSPACKFLA EKCLNNQQLH FLHIGSCQDG RQLEWGLERT RLSSNSTKKE SCGYDTCYDW EKCSASTSKC VCLLPPQCFK GGNQLYCVKM GSSTSEKTLN ICEVGTIRCA NRKMEILHPG KCLA
• Endotoxin: <1.0eu per="" 1µg="" (determined="" by="" the="" lal="">
• Purity: >95%
• Applications: SDS-PAGE; WB; ELISA; IP.
• Storage: Avoid repeated freeze/thaw cycles. Store at 2-8 centigrade for one month. Aliquot and store at -80 centigrade for 12 months.
• Reconstitution: Reconstitute in sterile PBS, pH7.2-pH7.4.

Gene Information

• Gene Name: C6 complement component 6 [ Homo sapiens ]
• Official Symbol: C6
• Synonyms: C6; complement component 6; complement component C6
• Gene ID: 729
• mRNA Refseq: NM_000065
• Protein Refseq: NP_000056
• MIM: 217050
• UniProt ID: P13671
• Chromosome Location: 5p13
• Pathway: Complement Activation, Classical Pathway, organism-specific biosystem; Complement and Coagulation Cascades, organism-specific biosystem; Complement and coagulation cascades, organism-specific biosystem; Complement and coagulation cascades, conserved biosystem; Complement cascade, organism-specific biosystem; Immune System, organism-specific biosystem; Innate Immune System, organism-specific biosystem
• Function: protein binding