C6

  • Official Full Name

    complement component 6

  • Overview

    This gene encodes a component of the complement cascade. The encoded protein is part of the membrane attack complex that can be incorporated into the cell membrane and cause cell lysis. Mutations in this gene are associated with complement component-6 deficiency. Transcript variants encoding the same protein have been described.[provided by RefSeq, Nov 2012]

  • Synonyms

    C6;complement component 6;complement component C6

Recombinant Proteins

  • Human
  • Rat
  • Zebrafish
  • Chicken
  • E.coli
  • Wheat Germ
  • Mammalian Cell
  • HEK293
  • Human Cell
  • Normal human serum (shown by certified tests to be negative for HBsAg, HTLV-I/II, STS and for antibodies to HCV, HIV-1 and HIV-II)
  • In Vitro Cell Free System
  • Human Plasma
  • His&T7
  • GST
  • His
  • Non
  • His&Fc&Avi
Cat.# Product name Source (Host) Species Tag Protein Length Price
C6-10552H Recombinant Human C6 protein, His/T7-tagged E.coli Human His&T7 Gln682~Ala934
C6-10553H Recombinant Human C6, GST-tagged E.coli Human GST 586-934a.a.
C6-0098H Recombinant Human C6 Protein, GST-Tagged Wheat Germ Human GST
C6-1054R Recombinant Rat C6 Protein Mammalian Cell Rat His
C6-1055H Recombinant Human C6 protein, His-tagged HEK293 Human His Met1-Ala934
C6-10910Z Recombinant Zebrafish C6 Mammalian Cell Zebrafish His
C6-3905C Recombinant Chicken C6 Mammalian Cell Chicken His
C6-8191H Recombinant Human C6 protein, His & T7-tagged E.coli Human His&T7 Gln682~Ala934
C6-1647HCL Recombinant Human C6 cell lysate Human Cell Human Non
C6-0619H Recombinant Human C6 Protein (Gln682-Ala934), N-His-tagged E.coli Human His Gln682-Ala934
C6-101H Native Human C6 Protein Normal human serum (shown by certified tests to be negative for HBsAg, HTLV-I/II, STS and for antibodies to HCV, HIV-1 and HIV-II) Human Non
C6-2678HF Recombinant Full Length Human C6 Protein, GST-tagged In Vitro Cell Free System Human GST Full L. 934 amino acids
C6-55H Native Human Complement C6 Human Plasma Human Non
C6-712R Recombinant Rat C6 Protein, His (Fc)-Avi-tagged HEK293 Rat His&Fc&Avi
C6-712R-B Recombinant Rat C6 Protein Pre-coupled Magnetic Beads HEK293 Rat

    Involved Pathway

    C6 involved in several pathways and played different roles in them. We selected most pathways C6 participated on our site, such as Complement and coagulation cascades,Prion diseases,Systemic lupus erythematosus, which may be useful for your reference. Also, other proteins which involved in the same pathway with C6 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Prion diseases PRKACG,Hc,C8B,PRKACB,IL6,C8A,MAP2K2,MAPK1,PRKACA,CASP12
    Systemic lupus erythematosus C1RA,HIST1H4N,HIST1H2BA,SNRPD3,HIST1H2AM,SNRPB,HIST1H4H,C1R,HIST1H2AH,HIST1H4F
    Complement and coagulation cascades FGG,C4BPA,BDKRB1,C8A,FGA,CFD,CR1L,C1R,F8,SERPINA1E

    Protein Function

    C6 has several biochemical functions, for example, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by C6 itself. We selected most functions C6 had, and list some proteins which have the same functions with C6. You can find most of the proteins on our site.

    Function Related Protein
    protein binding RCC1,JAM2,ERCC6,AP5Z1,KIAA1609,IMMT,BCKDHB,RNF14,BABAM1,ARID3B

    Interacting Protein

    C6 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with C6 here. Most of them are supplied by our site. Hope this information will be useful for your research of C6.

    ABL1;FYN;NCK1;GRB2;SART3;d-mannose

    Resources

    Research Area

    Membrane Attack Complex (MAC)

    References

    • Prantner, AM; Turini, M; et al. Anti-Mesothelin Nanobodies for Both Conventional and Nanoparticle-Based Biomedical Applications. JOURNAL OF BIOMEDICAL NANOTECHNOLOGY 11:1201-1212(2015).
    • Tiezzi, F; Parker-Gaddis, KL; et al. A Genome-Wide Association Study for Clinical Mastitis in First Parity US Holstein Cows Using Single-Step Approach and Genomic Matrix Re-Weighting Procedure. PLOS ONE 10:-(2015).

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