Recombinant Human C1S

• Cat.No.: C1S-26615TH
• Product Overview: Recombinant full length Human C1s with N terminal proprietary tag; Predicted MW 101.75 kDa.

Specification

• Species: Human
• Source: Wheat Germ
• Tag: Non
• Protein Length: 688 amino acids
• Description: This gene encodes a serine protease, which is a major constituent of the human complement subcomponent C1. C1s associates with two other complement components C1r and C1q in order to yield the first component of the serum complement system. Defects in this gene are the cause of selective C1s deficiency.
• Molecular Weight: 101.750kDa inclusive of tags
• Form: Liquid
• Purity: Proprietary Purification
• Storage buffer: pH: 8.00Constituents:0.3% Glutathione, 0.79% Tris HCl
• Storage: Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles.
• Sequences of amino acids: MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSW DIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEG RLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERF TGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPP EYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENS RCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVF VAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQK KGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQIT CLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCG IPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGE YHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIG GSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGN REPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVP EGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSDYNLM DGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKV EKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQD PNDKTKFYAAGLVSWGPQCGTYGLYTRVKNYVDWIMKTMQ ENSTPRED
• Sequence Similarities: Belongs to the peptidase S1 family.Contains 2 CUB domains.Contains 1 EGF-like domain.Contains 1 peptidase S1 domain.Contains 2 Sushi (CCP/SCR) domains.

Gene Information

• Gene Name: C1S complement component 1, s subcomponent [ Homo sapiens ]
• Official Symbol: C1S
• Synonyms: C1S; complement component 1, s subcomponent; complement C1s subcomponent
• Gene ID: 716
• mRNA Refseq: NM_001734
• Protein Refseq: NP_001725
• MIM: 120580
• Uniprot ID: P09871
• Chromosome Location: 12p13
• Pathway: Classical antibody-mediated complement activation, organism-specific biosystem; Complement Activation, Classical Pathway, organism-specific biosystem; Complement and Coagulation Cascades, organism-specific biosystem; Complement and coagulation cascades, organism-specific biosystem; Complement and coagulation cascades, conserved biosystem
• Function: calcium ion binding; peptidase activity; serine-type endopeptidase activity