C1s
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Official Full Name
complement component 1, s subcomponent -
Overview
This gene encodes a serine protease, which is a major constituent of the human complement subcomponent C1. C1s associates with two other complement components C1r and C1q in order to yield the first component of the serum complement system. Defects in this gene are the cause of selective C1s deficiency. [provided by RefSeq, Mar 2009] -
Synonyms
C1S;complement component 1, s subcomponent;complement C1s subcomponent;C1 esterase;basic proline-rich peptide IB-1;complement component 1 subcomponent s
Recombinant Proteins
- Human
- Rat
- Chicken
- E.coli
- Mammalian cells
- Mammalian Cell
- Wheat Germ
- HEK293
- E. coli
- In Vitro Cell Free System
- HEK293T
- GST
- His
- Non
- His&T7
- N-10×His and C-Myc
- His&Fc&Avi
- Myc&DDK
Involved Pathway
C1s involved in several pathways and played different roles in them. We selected most pathways C1s participated on our site, such as Complement and coagulation cascades,Pertussis,Staphylococcus aureus infection, which may be useful for your reference. Also, other proteins which involved in the same pathway with C1s were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Pertussis | IL12A,C1R,CD14,C5,MAPK10,GNAI3,C4BPA,IL12B,C1QC,CALM2 |
| Staphylococcus aureus infection | FCGR2B,C1RA,FCGR1,HLA-DQA1,FPR1,DSG1,HLA-DRA,Itgam&Itgb2,FCGR3B,SELP |
| Systemic lupus erythematosus | CD86,HIST1H2AB,C1R,GM6026,C2,HIST1H2BD,HLA-DRB4,C6,HIST2H3A,HIST1H2BE |
| Complement and coagulation cascades | SERPINF2,Serpina1c,BDKRB1,C8B,C4A,C5,PLAUR,C1R,GM5077,SERPINA1A |
Protein Function
C1s has several biochemical functions, for example, calcium ion binding,identical protein binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by C1s itself. We selected most functions C1s had, and list some proteins which have the same functions with C1s. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| calcium ion binding | THBS1,PCDH1G22,CDH12,EHD3,JAG1B,PTBP3,SPOCK3,FKBP10B,VSNL1A,EGFL7 |
| serine-type endopeptidase activity | PRSS28,PLAUB,FURINB,GZMK,PIK3IP1,PLAT,Acr,F2,HTRA2,PRSS22 |
| protein binding | FAM184A,ITGB3B,EFCAB4B,SCN5A,KLHL20,LARP1,SCRIB,C3orf62,CARKD,SMCP |
| identical protein binding | HCN2,AXIN1,BAIAP2,C,PHC2,CLDN6,TYROBP,PDGFB,SF1,ATL1 |
Interacting Protein
C1s has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with C1s here. Most of them are supplied by our site. Hope this information will be useful for your research of C1s.
C1R;calcium(2+);Dlg4;q7ckm5_yerpe;eutG;yrbF;q81um1_bacan;q81ux8_bacan;emrR;d-mannose
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References
- Keizer, MP; Pouw, RB; et al. TFPI inhibits lectin pathway of complement activation by direct interaction with MASP-2. EUROPEAN JOURNAL OF IMMUNOLOGY 45:544-550(2015).
- Muia, J; Zhu, J; et al. Allosteric activation of ADAMTS13 by von Willebrand factor. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 111:18584-18589(2014).
