Recombinant Human BRCA1 protein, GST-tagged

• Cat.No.: BRCA1-42H
• Product Overview: Recombinant Human BRCA1(1,634-1,863 aa) fused with GST tag at N-terminal was expressed in E. coli.

Specification

• Source: E. coli
• Species: Human
• Tag: GST
• Form: 50 mM Tris-HCl, pH 8.0, containing 150 mM sodium chloride and 20% glycerol
• Molecular Mass: 53.3 kDa
• Purity: ≥90%
• Storage: ≥6 months at -80 centigrade; avoid freeze/thaw cycles by aliquoting protein.
• Protein length: 1634-1863 a.a.

Gene Information

• Gene Name: BRCA1 breast cancer 1, early onset [ Homo sapiens ]
• Official Symbol: BRCA1
• Synonyms: BRCA1; breast cancer 1, early onset; breast cancer type 1 susceptibility protein; BRCA1/BRCA2 containing complex; subunit 1; BRCC1; PPP1R53; protein phosphatase 1; regulatory subunit 53; RNF53; RING finger protein 53; BRCA1/BRCA2-containing complex, subunit 1; protein phosphatase 1, regulatory subunit 53; breast and ovarian cancer susceptibility protein 1; breast and ovarian cancer sususceptibility protein 1; IRIS; PSCP; BRCAI; PNCA4; BROVCA1
• Gene ID: 672
• mRNA Refseq: NM_007294
• Protein Refseq: NP_009225
• MIM: 113705
• UniProt ID: P38398
• Chromosome Location: 17q21-q24
• Pathway: ATF-2 transcription factor network, organism-specific biosystem; ATM mediated phosphorylation of repair proteins, organism-specific biosystem; ATM mediated response to DNA double-strand break, organism-specific biosystem; Androgen Receptor Signaling Pathway, organism-specific biosystem; Aurora A signaling, organism-specific biosystem; BARD1 signaling events, organism-specific biosystem; BRCA1-associated genome surveillance complex (BASC), organism-specific biosystem
• Function: DNA binding; DNA binding; RNA binding; androgen receptor binding; damaged DNA binding; enzyme binding; ligase activity; metal ion binding; protein binding; transcription coactivator activity; transcription regulatory region DNA binding; tubulin binding; ubiquitin protein ligase binding; ubiquitin-protein ligase activity; contributes_to ubiquitin-protein ligase activity; zinc ion binding