BRCA1
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Official Full Name
breast cancer 1, early onset -
Overview
Breast Cancer Gene 1 (BRCA1) is phosphorylated at Ser1524, and occurs in response to ionizing and ultraviolet radiation. -
Synonyms
BRCA1;breast cancer 1, early onset;breast cancer type 1 susceptibility protein;BRCA1/BRCA2 containing complex;subunit 1;BRCC1;PPP1R53;protein phosphatase 1;regulatory subunit 53;RNF53;RING finger protein 53;BRCA1/BRCA2-containing complex, subunit 1;protein phosphatase 1, regulatory subunit 53;breast and ovarian cancer susceptibility protein 1;breast and ovarian cancer sususceptibility protein 1;IRIS;PSCP;BRCAI;PNCA4;BROVCA1
Recombinant Proteins
- Human
- Rat
- Mouse
- Cynomolgus
- Rhesus macaque
- Chicken
- E.coli
- Sf9 Insect Cell
- Sf21 Insect Cell
- Mammalian Cell
- Wheat Germ
- HEK293
- In Vitro Cell Free System
- Mouse
- GST
- Non
- His
- His&T7
- His&GST
- His&Fc&Avi
Involved Pathway
BRCA1 involved in several pathways and played different roles in them. We selected most pathways BRCA1 participated on our site, such as Fanconi anemia pathway,Ubiquitin mediated proteolysis,PIK-Akt signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with BRCA1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| MicroRNAs in cancer | NOTCH3,PDGFRB,THBS1,CDC25B,CD44,TP63,RPS6KA5,NOTCH2,PLCG2,NFKB1 |
| Fanconi Anemia Pathway | PALB2,RMI2,BRCA2,RPA1,RAD51,FANCM,BRIP1,HES1,STRA13,WDR48 |
| Ubiquitin mediated proteolysis | BIRC7,UBE2F,UBE3B,UBE4A,CBLC,SIAH2L,UBE2O,UBE4B,CDC16,NEDD4L |
| PIK-Akt signaling pathway | Gh,LAMA1,CREB3L3,OSM,MET,PDGFD,GNB3,IFNB1,PPP2R5A,LPAR5 |
Protein Function
BRCA1 has several biochemical functions, for example, DNA binding,RNA binding,androgen receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by BRCA1 itself. We selected most functions BRCA1 had, and list some proteins which have the same functions with BRCA1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| DNA binding | PMS2,ZNF74,THRAA,RAD51D,POLR2L,BHLHE22,ETS2,CCDC79,ZFP579,CHES1 |
| damaged DNA binding | RAD23A,XRCC1,MGMT,DCLRE1C,POLD1,RAD23AA,TDG,GTF2H3,EP300,RAD1 |
| RNA binding | LARP6,EIF4E1B,TRNAU1APA,RPS3,BXDC2,THOC3,RPS3A,RPL18,RBM4B,RBM20 |
| ubiquitin protein ligase binding | UBE2NB,SLC25A5,CKB,SQSTM1,UBE2C,CUL1A,RNF31,SMAD6,JKAMP,TRIM37 |
| androgen receptor binding | PARK7,PIAS2,KAT5,WIPI1,PRKCB,TCF21,DDX5,NCOA1,KDM3A,FOXP1 |
| ligase activity | MGRN1A,PELI2,UFL1,LIPT2,BIRC2,UBR1,NEDD4,CTPS1A,UBE2CBP,HECTD2 |
| tubulin binding | TTLL4,TPR,STMN2,KIF14,BIRC5,TBCC,RPS3,GPAA1,STMN1A,TPPP3 |
| ubiquitin-protein transferase activity | UBE2D4,RLIM,TRAF4A,RAG1,MKRN1,NSMCE1,UBE2C,TRAF3,FBXL5,BIRC8 |
| zinc ion binding | PRICKLE1B,RXRBB,MORC3,RORA,ISL2B,CAR5A,NR2F2,BLVRA,CPA3,EHMT1 |
Interacting Protein
BRCA1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with BRCA1 here. Most of them are supplied by our site. Hope this information will be useful for your research of BRCA1.
BRIP1;BARD1
Resources
Research Area
Tumor SuppressorsUbiquitin-related Molecules in the Akt Pathway
DNA Damage and Repair
Negative Regulators of the Jak/STAT Pathway
Positive Regulators of the Jak/STAT Pathway
E3 Ubiquitin Ligases
Breast Cancer Biomarkers
Ovarian Cancer Biomarkers
Tumor Antigens
Nucleotide Excision Repair/Transcription Coupled Repair
Related Services
Related Products
References
- Seksenyan, A; Kadavallore, A; et al. TOX3 is expressed in mammary ER+ epithelial cells and regulates ER target genes in luminal breast cancer. BMC CANCER 15:-(2015).
- Kast, K; Rhiem, K; et al. Familial Breast Cancer - Targeted Therapy in Secondary and Tertiary Prevention. BREAST CARE 10:27-31(2015).
