Recombinant Human brain expressed, X-linked 1, His-tagged

• Cat.No.: BEX1-224H
• Product Overview: BEX1, 1-125aa, Human, His tag, E.coli

Specification

• Description: Brain expressed, X-linked 1, also known as BEX1, is signaling adapter molecule involved in p75NTR/NGFR signaling. This protein plays a role in cell cycle progression and neuronal differentiation. This protein inhibits neuronal differentiation in response to nerve growth factor (NGF). It may act as a link between the cell cycle and neurotrophic factor signaling, possibly by functioning as an upstream modulator of receptor signaling, coordinating biological responses to external signals with internal cellular states. Recombinant human BEX1 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques.
• Source: E.coli
• Species: Human
• Tag: His-tag
• Form: Liquid. In 20mM Tris-HCl buffer (pH 8.0) containing 0.15M NaCl, 30% glycerol
• Molecular Mass: 17.2 kDa (148aa), confirmed by MALDI-TOF
• AA Sequence: MGSSHHHHHH SSGLVPRGSH MGSMESKEKR AVNSLSMENA NQENEEKEQV ANKGEPLALP LDAGEYCVPR GNRRRFRVRQ PILQYRWDMM HRLGEPQARM REENMERIGE EVRQLMEKLR EKQLSHSLRA VSTDPPHHDH HDEFCLMP
• Purity: >80% by SDS - PAGE
• Storage: Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -70C. Avoid repeated freezing and thawing cycles.
• Concentration: 0.25 mg/ml (determined by BCA assay)
• Protein length: 1-125 a.a.

Gene Information

• Gene Name: BEX1 brain expressed, X-linked 1 [ Homo sapiens ]
• Official Symbol: BEX1
• Synonyms: BEX1; brain expressed, X-linked 1; protein BEX1; brain-expressed X-linked protein 1; ovarian granulosa cell 13.0 kDa protein hGR74; BEX2; HBEX2; HGR74-h
• Gene ID: 55859
• mRNA Refseq: NM_018476
• Protein Refseq: NP_060946
• MIM: 300690
• UniProt ID: Q9HBH7
• Chromosome Location: Xq21-q23
• Pathway: p75(NTR)-mediated signaling, organism-specific biosystem
• Function: RNA polymerase II activating transcription factor binding