Recombinant Human BCR

• Cat.No.: BCR-26665TH
• Product Overview: Recombinant fragment, corresponding to N terminal amino acids 1-695 of Human Bcr expressed by baculovirus in Sf9 insect cells using an N-terminal tag, 120kDa.

Specification

• Description: A reciprocal translocation between chromosomes 22 and 9 produces the Philadelphia chromosome, which is often found in patients with chronic myelogenous leukemia. The chromosome 22 breakpoint for this translocation is located within the BCR gene. The translocation produces a fusion protein which is encoded by sequence from both BCR and ABL, the gene at the chromosome 9 breakpoint. Although the BCR-ABL fusion protein has been extensively studied, the function of the normal BCR gene product is not clear. The protein has serine/threonine kinase activity and is a GTPase-activating protein for p21rac. Two transcript variants encoding different isoforms have been found for this gene.
• Form: Liquid
• Storage buffer: Preservative: NoneConstituents: 25% Glycerol, 50mM Sodium chloride, 50mM Tris HCl, 0.25mM DTT, 0.1mM PMSF, pH 7.5
• Storage: Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles.
• Tag: Non
• Protein length: 1-695 a.a.

Gene Information

• Gene Name: BCR breakpoint cluster region [ Homo sapiens ]
• Official Symbol: BCR
• Synonyms: BCR; breakpoint cluster region; BCR1, D22S11; breakpoint cluster region protein; ALL; CML; D22S662; PHL
• Gene ID: 613
• mRNA Refseq: NM_004327
• Protein Refseq: NP_004318
• MIM: 151410
• Uniprot ID: P11274
• Chromosome Location: 22q11
• Pathway: Chronic myeloid leukemia, organism-specific biosystem; Chronic myeloid leukemia, conserved biosystem; Pathways in cancer, organism-specific biosystem; Regulation of RAC1 activity, organism-specific biosystem; Regulation of RhoA activity, organism-specific biosystem
• Function: ATP binding; GTPase activator activity; Rac GTPase activator activity; Rho guanyl-nucleotide exchange factor activity; guanyl-nucleotide exchange factor activity