BCR
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Official Full Name
breakpoint cluster region -
Overview
The Bcr gene was orginally identified by its presence in the chimeric Bcr-Abl oncogene. The amino-terminal region of Bcr contains an oligomerization domain, a serine/threonine kinase domain, and a region that binds SH2 domains. The middle of the protein h -
Synonyms
BCR;breakpoint cluster region;BCR1, D22S11;breakpoint cluster region protein;ALL;CML;D22S662;PHL;renal carcinoma antigen NY-REN-26;BCR1;D22S11;FLJ16453
Recombinant Proteins
- Human
- Mouse
- E.coli
- Insect Cell
- Sf9 Insect Cell
- HEK293
- Wheat Germ
- HEK293T
- Mamanlian cells
- His
- GST
- Myc&DDK
- Non
- Flag
Involved Pathway
BCR involved in several pathways and played different roles in them. We selected most pathways BCR participated on our site, such as Pathways in cancer,Chronic myeloid leukemia, which may be useful for your reference. Also, other proteins which involved in the same pathway with BCR were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Chronic myeloid leukemia | SHC4,PIK3R2,TGFBR2,TRP53,AKT1,MDM2,RELA,AKT2,PIK3CD,CCND1 |
| Pathways in cancer | MAPK3,FGF22,PIK3R5,BMP4,PLCB3,SKP2,MAPK9,PDGFRB,ARNT,NOS2 |
Protein Function
BCR has several biochemical functions, for example, ATP binding,GTPase activator activity,Rho guanyl-nucleotide exchange factor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by BCR itself. We selected most functions BCR had, and list some proteins which have the same functions with BCR. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | RELB,HILPDA,GNAS,CSNK1E,MIB1,MMP9,DAP3,EPN1,POR,Anks6 |
| protein tyrosine kinase activity | PTK2B,CSF1RA,ERBB4,TYK2,AXL,INSRA,LTK,MATK,TTN,FYNA |
| kinase activity | CAMK1DA,PIP5K2,TRIO,PRKG1A,PDXK,RPS6KA3A,TAOK1,PKN1B,STK35L,LRRK2 |
| protein serine/threonine kinase activity | STK11,BMPR2B,MAPK8A,RPS6KB2,GRK7B,RPS6KA1,MAP3K9,SMOK3A,VPRBP,SGK1 |
| enzyme binding | P4HB,CCDC99,TOP2B,PCCA,CYP2C8,UGT1A6,NOXO1,TOP2A,LUC7L2,DVL1 |
| GTPase activator activity | ARRB1,PLEKHG6,RGS11,RACGAP1,GARNL3,RAP1GAP2,BNIP2,ARHGAP4A,RGS10,ARHGAP35 |
| ATP binding | INSRA,ABCC2,CCT6B,VARS,PRKCQ,SGK1,DGKE,NEK5,INSRR,CBWD2 |
| Rho guanyl-nucleotide exchange factor activity | KALRN,ARHGEF18,ARHGEF15,FGD3,ABR,PLEKHG4,ARHGEF28,FARP2,TIAM2,DOCK9 |
Interacting Protein
BCR has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with BCR here. Most of them are supplied by our site. Hope this information will be useful for your research of BCR.
GRB2;APBA3;TNKS2;TP53
BCR Related Signal Pathway
Resources
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References
- Sagiv-Barfi, I; Kohrt, HEK; et al. Therapeutic antitumor immunity by checkpoint blockade is enhanced by ibrutinib, an inhibitor of both BTK and ITK. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 112:E966-E972(2015).
- McHeyzer-Williams, LJ; Milpied, PJ; et al. Class-switched memory B cells remodel BCRs within secondary germinal centers. NATURE IMMUNOLOGY 16:296-U129(2015).
