Recombinant Human BCL2L2 protein

• Cat.No.: BCL2L2-1588H
• Product Overview: Recombinant Human BCL2L2 protein was expressed in Escherichia coli.

Specification

• Description: This gene encodes a member of the BCL-2 protein family. The proteins of this family form hetero- or homodimers and act as anti- and pro-apoptotic regulators. Expression of this gene in cells has been shown to contribute to reduced cell apoptosis under cytotoxic conditions. Studies of the related gene in mice indicated a role in the survival of NGF- and BDNF-dependent neurons. Mutation and knockout studies of the mouse gene demonstrated an essential role in adult spermatogenesis. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the neighboring downstream PABPN1 (poly(A) binding protein, nuclear 1) gene.
• Source: E.coli
• Species: Human
• Form: 0.2μm Filtered concentrated solution in 25 mM Hepes, pH 7.4, 100 mM KCl, 10 % Glycerol, 5 % Trehalose, 0.02 % Tween-80.
• Molecular Mass: Approximately 18.6 kDa, a single non-glycosylated polypeptide chain containing 171 amino acids.
• Protein length: 171
• AA Sequence: ATPASAPDTRALVADFVGYKLRQKG YVCGAGPGEGPAADPLHQAMRAAGD EFETRFRRTFSDLAAQLHVTPGSAQ QRFTQVSDELFQGGPNWGRLVAFFV FGAALCAESVNKEMEPLVGQVQEWM VAYLETQLADWIHSSGGWAEFTALY GDGALEEARRLREGNWASVRT
• Endotoxin: Less than 1 EU/µg of rHuBcl-w as determined by LAL method.
• Purity: >95% by SDS-PAGE and HPLC analysis.
• Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 6 months from date of receipt, -20 to -70 centigrade as supplied. 3 months, -20 to -70 centigrade under sterile conditions after opening.
• Tag: Non

Gene Information

• Gene Name: BCL2L2
• Official Symbol: BCL2L2
• Synonyms: BCL2L2; BCL2-like 2; bcl-2-like protein 2; BCL W; KIAA0271; PPP1R51; protein phosphatase 1; regulatory subunit 51; apoptosis regulator BCL-W; protein phosphatase 1, regulatory subunit 51; BCLW; BCL-W; BCL2-L-2
• Gene ID: 599
• mRNA Refseq: NM_001199839
• Protein Refseq: NP_001186768
• MIM: 601931
• UniProt ID: Q92843