Recombinant Human B lymphoid Tyrosine Kinase, GST-tagged, Active

• Cat.No.: BLK-250H
• Product Overview: Recombinant full-length human BLK was expressed by baculovirus inSf9 insect cellsusing a N-terminal GST tag. MW = 84 kDa.

Specification

• Species: Human
• Source: Sf9 Cells
• Tag: GST
• Description: BLK, also known as B lymphoid kinase, is a 55 kd tyrosine kinases with a SH3, SH2 and catalytic domains that contain consensus sequences of the src protein tyrosine kinase family. BLK is expressed specifically in the B cell lineage and plays a role in signal transduction pathway that is restricted to B lymphoid cells. Stimulation of resting B-lymphocytes with antibodies to surface immunoglobulin (sIgD or sIgM) induces activation of BLK.
• Sequence: Full-length.
• Applications: Kinase Assay, Western Blot.
• Storage And Stability: Store product at –70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Gene Information

• Gene Name: BLK B lymphoid tyrosine kinase [ Homo sapiens ]
• Synonyms: B lymphoid tyrosine kinase;MGC10442; BLK; BLK nonreceptor tyrosine kinase; EC 2.7.10.2; p55-BLK; B lymphocyte kinase
• Gene ID: 640
• mRNA Refseq: NM_001715
• Protein Refseq: NP_001706
• MIM: 191305
• UniProt ID: P51451
• Chromosome Location: 8p23-p22
• Function: non-membrane spanning protein tyrosine kinase activity; ATP binding; nucleotide binding; protein binding; transferase activity