BLK
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Official Full Name
B lymphoid tyrosine kinase -
Overview
This gene encodes a nonreceptor tyrosine-kinase of the src family of proto-oncogenes that are typically involved in cell proliferation and differentiation. The protein has a role in B-cell receptor signaling and B-cell development. The protein also stimulates insulin synthesis and secretion in response to glucose and enhances the expression of several pancreatic beta-cell transcription factors. -
Synonyms
BLK;B lymphoid tyrosine kinase;tyrosine-protein kinase Blk;MGC10442;p55-Blk;b lymphocyte kinase;BLK nonreceptor tyrosine kinase;MODY11
Recombinant Proteins
- Human
- Mouse
- Zebrafish
- E.coli
- Insect Cells
- Sf9 Insect Cell
- Hi-5 Insect Cell
- Wheat Germ
- Mammalian Cell
- Hi-5 Inscet Cell
- Insect Cell
- HEK293
- In Vitro Cell Free System
- Insect (sf21)
- GST
- His&GST
- His
- Non
- His&Fc&Avi
Involved Pathway
BLK involved in several pathways and played different roles in them. We selected most pathways BLK participated on our site, such as Adaptive Immune System,Alpha-synuclein signaling,Antigen activates B Cell Receptor (BCR) leading to generation of second messengers, which may be useful for your reference. Also, other proteins which involved in the same pathway with BLK were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| B Cell Receptor Signaling Pathway | Cd79a,PIK3AP1,INPP5D,DAPP1,IKBKB,CTNNB2,DOK1,PILRB,ACTR2,DUSP6 |
| Alpha-synuclein signaling | PARK7,TOR1A,STUB1,FKBP1A,CSNK2A1,KLK6 |
| Apoptosis Modulation and Signaling | BIK,DFFA,CDKN2A,BOK,BCL2L11,CRADD,BCL2L10,SEPT4,CASP2,CAPNS1 |
| CXCR4-mediated signaling events | CFL1,ADRBK1,PAG1,ARR3,MAPKAP1,JAK2,GNA13,GNB2L1,CSK,CRK |
| Antigen activates B Cell Receptor (BCR) leading to generation of second messengers | ITPR2,PIK3AP1,IGKC,AHCYL1,AKR1C1,IGHM,STIM1B,IGLC2,SRMS,IGKV1-5 |
| Class I PI3K signaling events | ARF1,ADAP1,ITK,PLEKHA1 |
| EPHA forward signaling | ARHGEF15,EFNA2,EPHA2,CRKL,EFNA1,EFNA5,EFNA3 |
| Adaptive Immune System | LILRB4,TRIM9,AP1B1,RNF123,MAPKAP1,NA,CD300C,SRMS,SIGLEC11,CTSC |
Protein Function
BLK has several biochemical functions, for example, ATP binding,non-membrane spanning protein tyrosine kinase activity,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by BLK itself. We selected most functions BLK had, and list some proteins which have the same functions with BLK. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | BCL7A,BATF3,ASUN,ALOX12B,LRRFIP1,O3far1,SMCO4,BRAF,NME7,FAM32A |
| ATP binding | TNK1,VRK2,ABCC8,ENTPD3,IGF1R,MAP2K4A,KIF25,AK4,MAPK12,ATAD2B |
| receptor binding | FGF6B,FGF8A,NPFFL,AMN,APOL2,TAC3,MCHR1,FYNA,PGR,C1QTNF2 |
| protein tyrosine kinase activity | DYRK1B,PTK2AB,TTN,ERBB3A,INSR,INSRB,MAP3K9,FYNA,ALK,CLK3 |
| non-membrane spanning protein tyrosine kinase activity | SYK,PKDCC,YES1,WEE1,BTK,RIPK2,FRK,YRK,ABL1,ZAP70 |
Interacting Protein
BLK has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with BLK here. Most of them are supplied by our site. Hope this information will be useful for your research of BLK.
EGFR;80125;STAT3;EFS;saicar;ERBB2;MET;AR;KIT
Resources
Research Area
Src KinasesNegative Regulators of the Jak/STAT Pathway
B Cell Receptor-Associated Proteins
Related Services
Related Products
References
- Carmona, FD; Martin, J; et al. Genetics of vasculitis. CURRENT OPINION IN RHEUMATOLOGY 27:10-17(2015).
- Sugiura, T; Kawaguchi, Y; et al. Association between a C8orf13-BLK Polymorphism and Polymyositis/Dermatomyositis in the Japanese Population: An Additive Effect with STAT4 on Disease Susceptibility. PLOS ONE 9:-(2014).
