Recombinant Human AXIN1 Protein, GST-Tagged

• Cat.No.: AXIN1-02H
• Product Overview: Recombinant Human AXIN1 Protein, GST-Tagged was expressed in sf9 cell.

Specification

• Species: Human
• Source: Sf9 Cells
• Tag: GST
• Description: This gene encodes a cytoplasmic protein which contains a regulation of G-protein signaling (RGS) domain and a dishevelled and axin (DIX) domain. The encoded protein interacts with adenomatosis polyposis coli, catenin beta-1, glycogen synthase kinase 3 beta, protein phosphate 2, and itself. This protein functions as a negative regulator of the wingless-type MMTV integration site family, member 1 (WNT) signaling pathway and can induce apoptosis. The crystal structure of a portion of this protein, alone and in a complex with other proteins, has been resolved. Mutations in this gene have been associated with hepatocellular carcinoma, hepatoblastomas, ovarian endometriod adenocarcinomas, and medullablastomas. Alternative splicing results in multiple transcript variants.
• Molecular Mass: ~135 kDa
• Purity: ≥75%
• Usage: Research Use Only
• Storage: Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
• Concentration: 0.05 µg/µl
• Storage Buffer: Recombinant protein stored in 50mM Tris-HCl, pH 7.5,50mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT,0.1mM PMSF, 25% glycerol.
• Shipping: Shipped with ice pack.

Gene Information

• Gene Name: AXIN1 axin 1 [ Homo sapiens (human) ]
• Official Symbol: AXIN1
• Synonyms: AXIN; PPP1R49
• Gene ID: 8312
• mRNA Refseq: NM_003502.4
• Protein Refseq: NP_003493.1
• MIM: 603816
• UniProt ID: O15169