AXIN1
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Official Full Name
axin 1 -
Overview
Component of the beta-catenin destruction complex required for regulating CTNNB1 levels through phosphorylation and ubiquitination, and modulating Wnt-signaling. Controls dorsoventral patterning via two opposing effects; down-regulates CTNNB1 to inhibit the Wnt signaling pathway and ventralize embryos, but also dorsalizes embryos by activating a Wnt-independent JNK signaling pathway. In Wnt signaling, probably facilitates the phosphorylation of CTNNB1 and APC by GSK3B. Likely to function as a tumor suppressor. Facilitates the phosphorylation of TP53 by HIPK2 upon ultraviolet irradiation. Enhances TGF-beta signaling by recruiting the RNF111 E3 ubiquitin ligase and promoting the degradation of inhibitory SMAD7. Also component of the AXIN1-HIPK2-TP53 complex which controls cell growth, apoptosis and development. -
Synonyms
AXIN1;axin 1;axin-1;PPP1R49;protein phosphatase 1;regulatory subunit 49;AI316800;AXIN;Axin 1;Axin-1;axin1;AXIN1_HUMAN;Axis inhibition protein 1;Axis Inhibitor 1;hAxin;Kb;Ki;kinky;knobbly;axis inhibition protein 1;protein phosphatase 1, regulatory subunit 49;AXIN
Recombinant Proteins
- Human
- Mouse
- Chicken
- Zebrafish
- Rat
- E. coli
- E.coli
- Wheat Germ
- HEK293
- E.Coli/Yeast
- Mammalian Cells
- Sf9 Cells
- His
- GST
- DDK
- Myc
- Avi
- Fc
- Flag
Involved Pathway
AXIN1 involved in several pathways and played different roles in them. We selected most pathways AXIN1 participated on our site, such as Wnt signaling pathway,Hippo signaling pathway,Signaling pathways regulating pluripotency of stem cells, which may be useful for your reference. Also, other proteins which involved in the same pathway with AXIN1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Basal cell carcinoma | GLI2,GLI3,WNT7A,GLI1,LEF1,WNT3,FZD6,WNT9B,HHIP,PTCH2 |
| Pathways in cancer | CCNE1,STK36,FLT3LG,IGF1R,MSH6,VEGFA,BIRC5,FGF18,FGFR3,ITGA6 |
| Signaling pathways regulating pluripotency of stem cells | MYF5,HAND1,ID3,FZD8,SMAD1,HOXB1,FZD1,INHBE,WNT7B,WNT10B |
| Hippo signaling pathway | BMP5,WWTR1,YWHAE,WWC1,GDF6,TEAD2,MOB1A,WNT9A,PRKCZ,WNT3 |
| Endometrial cancer | SOS1,TCF7L2,TRP53,PDPK1,PIK3R5,ARAF,CCND1,AXIN2,TP53,MAP2K1 |
| Wnt signaling pathway | RAC1B,FZD7,WNT8B,RHOAB,MAPK8,APC,PPARDB,PPP3CA,WNT10B,FBXW11A |
| Colorectal cancer | PIK3R1,APC2,TGFB1,SMAD4,MLH1,APPL1,CCND1,PIK3CG,RAC2,PIK3R5 |
Protein Function
AXIN1 has several biochemical functions, for example, GTPase activator activity,I-SMAD binding,R-SMAD binding. Some of the functions are cooperated with other proteins, some of the functions could acted by AXIN1 itself. We selected most functions AXIN1 had, and list some proteins which have the same functions with AXIN1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| armadillo repeat domain binding | CALCOCO1,CHD8,STRN,LEF1,TCF7L2,STRN4,CTNNBIP1,CNOT1,AXIN2 |
| identical protein binding | NUP153,SERPINB1A,NUFIP1,RELA,CREBZF,ESR1,B2M,PICK1,HCN2,ATG16L1 |
| GTPase activator activity | SGSM3,CHN1,RGS18,FAM13B1,CHML,CHN2,LLGL2,ARHGAP25,RASAL3,ACAP3B |
| signal transducer activity | F2RL2,LPAR2B,STAT4,TRAF3,ADRA2DB,OLFR958,OPN3,OLFR488,DRD4-RS,PLCH1 |
| I-SMAD binding | AXIN2,TGFBR1,CTNNB1,SMAD7,SMAD6,SMURF1,SMAD1,TGFB1I1,SMAD2,SMAD4 |
| protein kinase binding | RNF138,HIF1A,SHC4,B4GALT1,AKAP5,PDGFRB,CD24,GSTP2,PDCD10,PLK1 |
| protein binding | FLOT2,RBM4,UBXN8,WAC,DOCK2,P2RY1,DDIT3,UCHL1,ARL6IP1,GLS2 |
| R-SMAD binding | SMAD2,FOS,RANBP3,SMURF1,PARP1,JUN,SMAD3,ZEB2,PMEPA1,SMAD6 |
| SMAD binding | SMURF2,COL3A1,SNW1,ACVR1B,SKILB,ACVR1,SKOR2,EP300,TGFBR2,DAB2 |
Interacting Protein
AXIN1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with AXIN1 here. Most of them are supplied by our site. Hope this information will be useful for your research of AXIN1.
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References
- Valenti, F; Ibetti, J; et al. The Increase in Maternal Expression of axin1 and axin2 Contribute to the Zebrafish Mutant Ichabod Ventralized Phenotype. JOURNAL OF CELLULAR BIOCHEMISTRY 116:418-430(2015).
- Siwek, M; Slawinska, A; et al. A quantitative trait locus for a primary antibody response to keyhole limpet hemocyanin on chicken chromosome 14-Confirmation and candidate gene approach. POULTRY SCIENCE 89:1850-1857(2010).
