Recombinant Human ATP2A2-eGFP Protein (M1-S1042 end), N-10×His/Strep II-tagged

• Cat.No.: ATP2A2-14H
• Product Overview: Recombinant human 10His-Strep II-eGFP-SERCA2b(M1-S1042 end) was expressed in mammalian cells.

Specification

• Species: Human
• Source: Mammalian Cells
• Tag: His&Strep II
• Protein Length: M1-S1042 end
• Description: This gene encodes one of the SERCA Ca(2+)-ATPases, which are intracellular pumps located in the sarcoplasmic or endoplasmic reticula of the skeletal muscle. This enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol into the sarcoplasmic reticulum lumen, and is involved in regulation of the contraction/relaxation cycle. Mutations in this gene cause Darier-White disease, also known as keratosis follicularis, an autosomal dominant skin disorder characterized by loss of adhesion between epidermal cells and abnormal keratinization. Other types of mutations in this gene have been associated with various forms of muscular dystrophies. Alternative splicing results in multiple transcript variants encoding different isoforms.
• Form: Liquid
• Endotoxin: < 0.01 EU/μg of the protein
• Purity: 85%
• Stability: Samples are stable for up to twelve months from date of receipt at -20 to -80 centigrade
• Storage: Store it under sterile conditions at -20 to -80 centigrade. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
• Storage Buffer: Supplied as sterile 50 mM HEPES pH 7.5, 100 mM KCl , 1mM DTT, 1mM CaCl2, 1mM MgCl2, 0.001% (w/v) LMNG
• Shipping: It is shipped out with blue ice.

Gene Information

• Gene Name: ATP2A2 ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2 [ Homo sapiens (human) ]
• Official Symbol: ATP2A2
• Synonyms: ATP2A2; ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2; DD; DAR; ATP2B; SERCA2; sarcoplasmic/endoplasmic reticulum calcium ATPase 2; ATPase Ca++ transporting cardiac muscle slow twitch 2; ATPase, Ca++ dependent, slow-twitch, cardiac muscle-2; SR Ca(2+)-ATPase 2; calcium pump 2; cardiac Ca2+ ATPase; endoplasmic reticulum class 1/2 Ca(2+) ATPase; EC 7.2.2.10
• Gene ID: 488
• mRNA Refseq: NM_001681
• Protein Refseq: NP_001672
• MIM: 108740
• UniProt ID: P16615