ATP2A2
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Official Full Name
ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 -
Synonyms
Serca2;SercaII
Recombinant Proteins
- Human
- Mouse
- Chicken
- Rat
- E.coli
- Mammalian Cells
- Wheat Germ
- HEK293
- In Vitro Cell Free System
- His
- GST
- Non
- Strep II
- Avi
- Fc
Involved Pathway
ATP2A2 involved in several pathways and played different roles in them. We selected most pathways ATP2A2 participated on our site, such as Calcium signaling pathway,cGMP-PKG signaling pathway,cAMP signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with ATP2A2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Arrhythmogenic right ventricular cardiomyopathy (ARVC) | DES,CACNA2D1,CACNG7,ITGA8,RYR2,SGCA,ITGB6,LEF1,ITGB5,ITGA1 |
| Calcium signaling pathway | CAMK2D1,PDE1C,CHRM1,PRKCA,P2RX3B,P2RX2,CAMK2G1,PLCB2,HTR6,AGTR1B |
| Adrenergic signaling in cardiomyocytes | PPP2R5E,ADRA1BB,CALM2,ATF4,CALM2A,PIK3R3A,ADRB3A,CACNG1,TPM3,ACTC1B |
| Hypertrophic cardiomyopathy (HCM) | DMD,ITGA9,PRKAG2,CACNA2D3,ITGA10,ITGB1,TPM2,PRKAA2,DES,LMNA |
| Dilated cardiomyopathy | ITGB4,IGF1,CACNB2,DMD,TNNC1,ITGB7,TPM1,DES,TGFB3,Adcy4 |
| cGMP-PKG signaling pathway | IRS1,GUCY1B3,ATP2B4,PLN,CALML5,IRS2,GNA12,ITPR3,CALML3,RAF1 |
| Pancreatic secretion | ATP1A3,PRSS3,ATP2B1,SLC4A4,KCNQ1,RAB11A,RAB27B,CELA3B,TRPC1,BST1 |
| Thyroid hormone signaling pathway | SLC16A2,PRKCG,PLN,PIK3CD,HDAC3,ESR1,PIK3R5,ATP1B4,ACTB,SLC16A10 |
| cAMP signaling pathway | HTR1B,CNGA2,FSHB,GRIA3,CALM3,FSHR,PPARA,NPY1R,RRAS2,RAC1 |
Protein Function
ATP2A2 has several biochemical functions, for example, ATP binding,S100 protein binding,calcium ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ATP2A2 itself. We selected most functions ATP2A2 had, and list some proteins which have the same functions with ATP2A2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ATP binding | SRMS,ULK3,ATP2A1L,SRX1,MYH1,PLK3,TDRD12,LMTK2,DARS2,BAT1 |
| calcium ion binding | MYL9,CBL,PLCH1,SPNA2,PPEF1,MYL12A,ASPN,EEF2K,RET,EFHB |
| protein binding | KTN1,QRICH1,ZNF614,ZFP2,TOLLIP,CCK,AP5Z1,AEN,RRS1,FAM118B |
| enzyme binding | CD40,ESR2,HAND1,ATP6AP2,PEBP1,PIAS3,EHHADH,RPS2,TTN,MARCH6 |
| calcium-transporting ATPase activity | ATP2C1,ATP2B4,ATP2B1,ATP2A2A,ATP2A3,ATP2A2B,ATP2B2,ATP2A1L,ATP2C2,ATP2B1B |
| protein C-terminus binding | PEX1,FOXN3,ATXN2,SP1,EFHC1,TRIM3,TOP2A,AP2A1,SCLT1,KSR1 |
| S100 protein binding | S100A1,ANXA2,DDX1,AGER,S100A6,AHNAK,FGF1A,S100B,EZR,KCNK3 |
Interacting Protein
ATP2A2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ATP2A2 here. Most of them are supplied by our site. Hope this information will be useful for your research of ATP2A2.
MYC;OPRD1;EGFR;CANX;ILK;env;PTP4A3;TNF;TNFRSF1A;TNFRSF1B;TRADD;PPP5C;TRAF6
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References
- Powell, H; Affolter, VK; et al. Combined decongestive therapy including equine manual lymph drainage to assist management of chronic progressive lymphoedema in draught horses. EQUINE VETERINARY EDUCATION 24:81-89(2012).
- Dally, S; Corvazier, E; et al. Multiple and diverse coexpression, location, and regulation of additional SERCA2 and SERCA3 isoforms in nonfailing and failing human heart. JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY 48:633-644(2010).
