Recombinant Human ATF4, His Cam-tagged

• Cat.No.: ATF4-3596H
• Product Overview: Recombinant human ATF4 protein, fused to His-Calmodulin tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques (1-351 aa).

Specification

• Species: Human
• Source: E.coli
• Tag: His&CaM
• ProteinLength: 1-351 a.a.
• Description: Activating transcription factor 4, also known as ATF4, belongs to a family of DNA-binding proteins that includes the AP-1 family of transcription factors, cAMP-response element binding proteins and CREB-like proteins. ATF4 encodes a transcription factor that was originally identified as a widely expressed mammalian DNA binding protein that could bind a tax-responsive enhancer element in the LTR of HTLV-1.
• Form: Liquid. In 20mM Tris-HCl buffer (pH 8.0) containing 1mM DTT, 10% glycerol
• Molecular Weight: 56.6 kDa (510aa)
• Purity: > 90% by SDS - PAGE
• Concentration: 0.5 mg/ml (determined by Bradford assay)
• Sequences of amino acids: MHHHHHHMAD QLTEEQIAEF KEAFSLFDKD GDGTITTKEL GTVMRSLGQN PTEAELQDMI NEVDADGNGT IDFPEFLTMM ARKMKDTDSE EEIREAFRVF DKDGNGYISA AELRHVMTNL GEKLTDEEVD EMIREADIDG DGQVNYEEFV QMMTAKGSHM TEMSFLSSEV LVGDLMSPFD QSGLGAEESL GLLDDYLEVA KHFKPHGFSS DKAKAGSSEW LAVDGLVSPS NNSKEDAFSG TDWMLEKMDL KEFDLDALLG IDDLETMPDD LLTTLDDTCD LFAPLVQETN KQPPQTVNPI GHLPESLTKP DQVAPFTFLQ PLPLSPGVLS STPDHSFSLE LGSEVDITEG DRKPDYTAYV AMIPQCIKEE DTPSDNDSGI CMSPESYLGS PQHSPSTRGS PNRSLPSPGV LCGSARPKPY DPPGEKMVAA KVKGEKLDKK LKKMEQNKTA ATRYRQKKRA EQEALTGECK ELEKKNEALK ERADSLAKEI QYLKDLIEEV RKARGKKRVP
• Storage: Can be stored at +4°C short term (1-2 weeks). For long term storage, aliquot and store at -20°C or -70°C. Avoid repeated freezing and thawing cycles.

Gene Information

• Gene Name: ATF4 activating transcription factor 4 (tax-responsive enhancer element B67) [ Homo sapiens ]
• Official Symbol: ATF4
• Synonyms: ATF4; CREB2; TXREB; CREB-2; TAXREB67; activating transcription factor 4 (tax-responsive enhancer element B67); cyclic AMP-dependent transcription factor ATF-4; OTTHUMP00000199130; OTTHUMP00000199131; DNA-binding protein TAXREB67; cAMP response element-binding protein 2; cAMP-dependent transcription factor ATF-4; cAMP-responsive element-binding protein 2; cyclic AMP-responsive element-binding protein 2; tax-responsive enhancer element-binding protein 67; Cyclic AMP-dependent transcription factor ATF-4; Activating transcription factor 4; Cyclic AMP-responsive element-binding protein 2; Tax-responsive enhancer element-binding protein 67; TaxREB67
• Gene ID: 468
• mRNA Refseq: NM_001675
• Protein Refseq: NP_001666
• MIM: 604064
• UniProt ID: P18848
• Chromosome Location: 22q13.1
• Function: DNA binding; RNA polymerase II transcription factor activity; protein binding; protein dimerization activity; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; specific RNA polymerase II transcription factor activity; transcription activator activity; transcription activator activity