ATF4
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Official Full Name
activating transcription factor 4 (tax-responsive enhancer element B67) -
Overview
This gene encodes a transcription factor that was originally identified as a widely expressed mammalian DNA binding;protein that could bind a tax-responsive enhancer element in the LTR of HTLV-1. The encoded protein was also isolated;and characterized as the cAMP-response element binding protein 2 (CREB-2). The protein encoded by this gene belongs to;a family of DNA-binding proteins that includes the AP-1 family of transcription factors, cAMP-response element binding;proteins (CREBs) and CREB-like proteins. These transcription factors share a leucine zipper region that is involved in;protein-protein interactions, located C-terminal to a stretch of basic amino acids that functions as a DNA binding;domain. Two alternative transcripts encoding the same protein have been described. Two pseudogenes are located on the;X chromosome at q28 in a region containing a large inverted duplication. -
Synonyms
ATF4;activating transcription factor 4 (tax-responsive enhancer element B67);TXREB;cyclic AMP-dependent transcription factor ATF-4;CREB 2;TAXREB67;DNA-binding protein TAXREB67;cAMP response element-binding protein 2;cAMP-dependent transcription fa
Recombinant Proteins
- Mouse
- Human
- Rhesus macaque
- Chicken
- Rat
- Mammalian Cells
- E.coli
- Wheat Germ
- HEK293
- In Vitro Cell Free System
- His
- T7
- GST
- Non
- Myc
- Avi
- Fc
Involved Pathway
ATF4 involved in several pathways and played different roles in them. We selected most pathways ATF4 participated on our site, such as MAPK signaling pathway,cGMP-PKG signaling pathway,Protein processing in endoplasmic reticulum, which may be useful for your reference. Also, other proteins which involved in the same pathway with ATF4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Cholinergic synapse | ITPR3,PRKACG,GNB2,KCNQ1,KCNJ3,JAK2,GNGT2,PIK3R1,KRAS,GNG13 |
| Neurotrophin signaling pathway | MAP2K7,SORT1,PIK3CB,TRAF6,MAP3K1,IRAK2,SH2B3,NFKBIB,PSEN2,NTRK1 |
| Non-alcoholic fatty liver disease (NAFLD) | AKT2,SDHC,PIK3CA,NDUFA12,PRKAG2,ADIPOR2,IL-8,NDUFS2,NDUFA13,COX6B2 |
| Estrogen signaling pathway | KCNJ3,PIK3R3,CALM3,HSP90B1,GABBR2,FKBP4,KCNJ5,HSPA6,PIK3R5,PLCB2 |
| Alcoholism | HIST1H3H,HDAC11,GNG10,HDAC3,H3F3B,HIST1H2BK,HIST1H2BM,H2AFX,MAPK3,HIST1H3A |
| HTLV-I infection | PCNA,BAX,MAP3K14,LTBR,LCK,CALR,TSPO,KAT2A,BCL2L1,PIK3R5 |
| Dopaminergic synapse | GNAQ,GRIN2A,CREB3L2,GNB3,PPP2R5E,CREB3L4,GNG2,GNB1,PPP3CA,ITPR3 |
| Cocaine addiction | TH,CREB3L3,SLC18A1,GNAI3,NFKB1,DRD1A,GRIN2D,GRIN3A,PRKACB,GNAS |
| Long-term potentiation | PRKACG,CAMK2G,PPP1CA,PPP1R1A,PPP3CA,GRM1,HRAS,CAMK2A,PPP3R1,PLCB2 |
Protein Function
ATF4 has several biochemical functions, for example, DNA binding,RNA polymerase II core promoter proximal region sequence-specific DNA binding,RNA polymerase II regulatory region sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ATF4 itself. We selected most functions ATF4 had, and list some proteins which have the same functions with ATF4. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | PCBD2,SETX,HOMER3,Serpina1b,RQCD1,EN1,ERP29,TLX3,IGFBP5,DYNAP |
| protein C-terminus binding | SP1,ERCC4,STIP1,ATP1B1,CDC20,VPS36,ZBTB16,CEP120,ITGB3BP,PRDX3 |
| transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding | MEIS1,CEBPZ,DDIT3,WT1,CAMTA1,MAFA,SFPI1,FOXK2,FOXJ1,FOS |
| RNA polymerase II regulatory region sequence-specific DNA binding | ZNF691,GATA2B,ZBTB16A,PHF21B,GATA2A,ETV3,SNAI1,E4F1,SOX13,RXRA |
| RNA polymerase II core promoter proximal region sequence-specific DNA binding | JUNBB,NFYC,KCNIP3,MYOD1,FLI1,SALL1,IRF1,SREBF2,MYF6,POU2F2 |
| transcription regulatory region DNA binding | SERPINB1A,TA,BCOR,ARID4A,CEBPA,TCF7L2,ZFP639,SALL1A,MSX2,GATA5 |
| DNA binding | SCML1,ZNF143B,PTF1A,ZNF580,GFI1B,RPAP1,GTF2IRD1,TBX6,SMARCB1A,THAP4 |
| RNA polymerase II transcription factor binding | WWP2,MIXL1,MTA2,GATA1,TRP53,NFATC1,GATA2B,MEF2A,GATA6,KDM1A |
| leucine zipper domain binding | DDIT3,ERC1,AATF,CRX,MKL1,PMF1,PAWR,DAPK3,KCNA3,NRL |
Interacting Protein
ATF4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ATF4 here. Most of them are supplied by our site. Hope this information will be useful for your research of ATF4.
BTRC;TRIB3;CREBZF;CEBPG
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References
- Rubovitch, V; Barak, S; et al. The Neuroprotective Effect of Salubrinal in a Mouse Model of Traumatic Brain Injury. NEUROMOLECULAR MEDICINE 17:58-70(2015).
- Hussain, H; Maldonado-Agurto, R; et al. The endoplasmic reticulum and unfolded protein response in the control of mammalian recombinant protein production. BIOTECHNOLOGY LETTERS 36:1581-1593(2014).
