Recombinant Human ARHGEF11 Protein, MYC/DDK-tagged

• Cat.No.: ARHGEF11-2697H
• Product Overview: Recombinant Human ARHGEF11 protein, fused to MYC/DDK-tagged at C-terminus, was expressed in HEK293.

Specification

• Description: Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein coupled receptors. The encoded protein may form a complex with G proteins and stimulate Rho-dependent signals. A similar protein in rat interacts with glutamate transporter EAAT4 and modulates its glutamate transport activity. Expression of the rat protein induces the reorganization of the actin cytoskeleton and its overexpression induces the formation of membrane ruffling and filopodia. Two alternative transcripts encoding different isoforms have been described.
• Source: HEK293
• Species: Human
• Tag: Myc&DDK
• Form: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
• Molecular Mass: 172.1 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Concentration: >50 ug/mL as determined by microplate BCA method

Gene Information

• Gene Name: ARHGEF11 Rho guanine nucleotide exchange factor (GEF) 11 [ Homo sapiens ]
• Official Symbol: ARHGEF11
• Synonyms: GTRAP48; PDZ-RHOGEF
• Gene ID: 9826
• mRNA Refseq: NM_014784
• Protein Refseq: NP_055599
• MIM: 605708
• UniProt ID: O15085