Recombinant Human ANO1 Protein, Met1-Ala333, N-His tagged

• Cat.No.: ANO1-12H
• Product Overview: Purified recombinant protein of Human anoctamin 1, calcium activated chloride channel (ANO1), transcript variant 1, Met1-Ala333, with N-terminal His tag, expressed in E.coli.

Specification

• Description: Enables calcium activated cation channel activity; intracellular calcium activated chloride channel activity; and iodide transmembrane transporter activity. Involved in cation transport; inorganic anion transport; and positive regulation of insulin secretion involved in cellular response to glucose stimulus. Located in apical plasma membrane and nucleoplasm.
• Source: E. coli
• Species: Human
• Tag: His
• Protein length: Met1-Ala333
• Molecular Mass: 38.5 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Notes: For testing in cell culture applications, please filter before use. Note that you may experience some loss of protein during the filtration process.
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade after receiving vials.
• Concentration: > 0.05 μg/μL as determined by microplate BCA method
• Storage Buffer: 50 mM Tris-HCl, pH 8.0, 8 M urea

Gene Information

• Gene Name: ANO1 anoctamin 1 [ Homo sapiens (human) ]
• Official Symbol: ANO1
• Synonyms: ANO1; anoctamin 1; DOG1; INDMS; MYMY7; TAOS2; ORAOV2; TMEM16A; anoctamin-1; Ca2+-activated Cl- channel; anoctamin 1, calcium activated chloride channel; calcium activated chloride channel; discovered on gastrointestinal stromal tumors protein 1; oral cancer overexpressed 2; transmembrane protein 16A (eight membrane-spanning domains); tumor-amplified and overexpressed sequence 2
• Gene ID: 55107
• mRNA Refseq: NM_018043
• Protein Refseq: NP_060513
• MIM: 610108
• UniProt ID: Q5XXA6