Recombinant Human Aminolevulinate, Delta-, Synthase 2, His-tagged

• Cat.No.: ALAS2-419H
• Product Overview: Recombinant Human ALAS (aminolevulinate, delta-, synthase 2) (a.a. 136-553) with N-terminal His tag, MW = 46 kDa, expressed in anE.Coliexpression system.

Specification

• Cat. No.: ALAS2-419H
• Description: Delta-aminolevulinate synthase 2 also known as ALAS2 is a protein which in humans is encoded by the ALAS2 gene. ALAS2 is an aminolevulinic acid synthase.The product of this gene specifies an erythroid-specific mitochondrially located enzyme. The encoded protein catalyzes the first step in the heme biosynthetic pathway. Defects in this gene cause X-linked pyridoxine-responsive sideroblastic anemia. Alternatively spliced transcript variants encoding different isoforms have been identified.
• Source: E.Coli.
• Formulated In: 25 mM Tris-HCl, pH 8.0, 100 mM NaCl, 0.05% Tween-20, 20% glycerol, 3 mM DTT, 20 μM pyridoxal 5' phosphate monohydrate.
• Purity: 90%.
• Application: Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling.
• Stability: >6 months at -80°C.
• Protein length: 136-553 a.a.

Gene Information

• Gene Name: ALAS2 aminolevulinate, delta-, synthase 2 [ Homo sapiens ]
• Synonyms: ALAS2; aminolevulinate, delta-, synthase 2; ASB; ANH1; XLSA; ALASE; ALAS-E; FLJ93603; 5-aminolevulinate synthase 2; delta-ALA synthetase; 5-aminolevulinic acid synthase; delta-aminolevulinate synthase; 5-aminolevulinate synthase, erythroid-specific, mitochondrial; EC 2.3.1.37;aminolevulinate, delta-, synthase 2 (sideroblastic/hypochromic anemia); OTTHUMP00000023388; OTTHUMP00000023389
• Gene ID: 212
• mRNA Refseq: NM_000032
• Protein Refseq: NP_000023
• MIM: 301300
• UniProt ID: P22557
• Chromosome Location: Xp11.21
• Pathway: Glycine, serine and threonine metabolism; Metabolic pathways; Porphyrin and chlorophyll metabolism
• Function: 5-aminolevulinate synthase activity; acyltransferase activity; coenzyme binding; glycine binding; protein binding; pyridoxal phosphate binding; transferase activity, transferring nitrogenous groups